Epstein-Barr virus-targeted therapy for AIDS-related primary lymphoma of the central nervous system.
Epstein-Barr virus-targeted therapy for AIDS-related primary lymphoma of the central nervous system.
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Epstein-Barr 病毒靶向治疗艾滋病相关的中枢神经系统原发性淋巴瘤。
DOI：
10.1016/s0140-6736(00)02879-8
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Sixbey,JW
中科院分区：
文献类型：
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作者：
Slobod,KS;Taylor,GH;Sandlund,JT;Furth,P;Helton,KJ;Sixbey,JW
病毒相关恶性疾病的EB病毒（EBV）靶向治疗策略只得到了敷衍的考虑，第一，因为潜伏疱疹病毒对抗病毒化疗是难治的，第二，因为EBV在维持恶性细胞表型中的作用一直不确定。本文报告两例艾滋病合并EB病毒相关原发性中枢神经系统淋巴瘤（PCNSL）患者，根据体外抗EB病毒活性，采用小剂量羟基脲治疗。这里获得的反应表明，在选择癌症的抗病毒方法的承诺。
Epstein-Barr virus (EBV) targeted therapeutic strategies for viral associated malignant diseases have received only perfunctory consideration, first, because latent herpesviruses have been intractable to antiviral chemotherapy and, second, because the role EBV has in maintenance of the malignant cell phenotype has been uncertain. Two patients with EBV related primary central nervous system lymphoma (PCNSL) in the setting of advanced AIDS, were treated with low dose hydroxyurea based on in vitro anti-EBV activity. The responses obtained here suggest the promise of antiviral approaches in select cancers.