Fasting blood glucose is a novel prognostic indicator for extranodal natural killer/T-cell lymphoma, nasal type
Fasting blood glucose is a novel prognostic indicator for extranodal natural killer/T-cell lymphoma, nasal type
复制标题
空腹血糖是鼻型结外自然杀伤/T 细胞淋巴瘤的新预后指标。
DOI：
10.1038/bjc.2012.566
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发表时间：
2013-02-05
影响因子：
8.8
通讯作者：
Huang, H.
中科院分区：
文献类型：
--
作者：
Cai, Q.;Luo, X.;Huang, H.
背景资料：鼻型结外自然杀伤（NK）/T细胞淋巴瘤（ENKTL）是一种预后不良的侵袭性疾病，需要进行危险分层。然而，ENKTL的预后尚未完全确定，需要补充。方法：回顾性分析130例ENKTL患者的临床资料，并进行单因素和多因素分析。结果：单因素分析和多因素分析均显示空腹血糖（FBG）>100 mg dl（-1）与ENKTL预后不良有关。诊断时FBG >100 mg dl（-1）的患者有更多不良临床特征，达到完全缓解率较低（P = 0.003），总生存率较差（P
Background: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an aggressive disease with poor prognosis, requiring risk stratification. However, the prognosis of ENKTL is not fully defined and needs supplementation. We hypothesised that fasting blood glucose (FBG) may be a new prognostic factor for ENKTL.Methods: We retrospectively analysed 130 patients newly diagnosed with ENKTL.Results: Both univariate analysis and multivariate analysis revealed that FBG >100 mg dl(-1) was associated with a poor outcome. Patients with FBG >100 mg dl(-1) at diagnosis had more adverse clinical features, achieved lower complete remission rates (P = 0.003) and had worse overall survival (P