Task-specific deactivation patterns in functional magnetic resonance imaging
Task-specific deactivation patterns in functional magnetic resonance imaging
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DOI：
10.1016/s0730-725x(99)00093-4
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发表时间：
1999-12-01
影响因子：
2.5
通讯作者：
Brodie, JD
中科院分区：
文献类型：
--
作者：
Hutchinson, M;Schiffer, W;Brodie, JD
一般而言，利用功能性磁共振成像技术进行的认知实验的图像分析强调了大脑中那些相对于参考状态信号强度增加与激活相关的区域。然而，最近的一些论文表明也存在失活区域。在这项研究中，我们使用了单变量分析和回波平面功能性磁共振成像来探讨参考状态与失活之间的关系。我们采用了两种二分的隐蔽任务，正字法词汇检索和纯视觉检索，与默数的参考状态（基线）进行对比。我们的分析得出了广泛的、特定任务的区域增减反应图谱。我们特别证明了减量反应不是由于参考状态下的激活。我们还证明了它们不是图像分析某一特定部分的人为产物，并提出它们代表一种生理的、特定任务的信号，应被视为代表大脑功能的神经网络的一个组成部分。（C）1999年爱思唯尔科学公司
In general, image analysis of cognitive experiments using functional magnetic resonance imaging techniques has emphasized those regions of the brain where increases in signal intensity, with regard to the reference state, are associated with activation. Nevertheless, a number of recent papers have shown that there are areas of deactivation as well. In this study, we have used a univariate analysis and echo-planar functional magnetic resonance imaging to address the relationship of the reference state to the deactivations. We employed two dichotomous covert tasks, orthographic lexical retrieval and pure visual retrieval, to contrast with the reference state (baseline) of silent counting. Our analysis yielded extensive, task-specific landscapes of regional incremental and decremental responses, We have specifically demonstrated that the decremental responses are not due to activation in the reference state. We have also demonstrated that they are not an artifact of a specific part of the image analysis, and propose that they represent a physiological, task specific signal that should be considered an integral component of neural networks representing brain function. (C) 1999 Elsevier Science Inc.