Disordered visual processing and oscillatory brain activity in autism and Williams Syndrome
Disordered visual processing and oscillatory brain activity in autism and Williams Syndrome
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DOI：
10.1097/00001756-200108280-00021
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发表时间：
2001-08-28
期刊：
影响因子：
1.7
通讯作者：
Johnson, MH
中科院分区：
文献类型：
--
作者：
Grice, SJ;Spratling, MW;Johnson, MH
自闭症和威廉姆斯综合症这两种发育障碍通常都被描述为难以整合感知特征，即将空间分离的元素结合成一个整体。众所周知，当大脑需要实现这种结合时，健康的成年人和婴儿会显示脑电图（EEG）伽马波段爆发（约40赫兹）。在这里，我们探讨自闭症和威廉姆斯综合征的伽马波段脑电图，并证明两种表型的差异异常。我们表明，尽管在认知水平上假定加工相似，但威廉姆斯综合征和自闭症的结合可以在神经生理水平上通过潜在脑振荡活动的不同异常分离。我们的研究是第一个确定与绑定相关的伽马脑电图在人类中可能紊乱的研究。[C] 2001 Lippincott Williams & Wilkins。
Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) gamma -band bursts (around 40 Hz) when the brain is required to achieve such binding. Here we explore gamma -band EEG in autism and Williams Syndrome and demonstrate differential abnormalities in the two phenotypes. We show that despite putative processing similarities at the cognitive level, binding in Williams syndrome and autism can be dissociated at the neurophysiological level by different abnormalities in underlying brain oscillatory activity. Our study is the first to identify that binding-related gamma EEG can be disordered in humans. NeuroReport 12:2697-2700 (C) 2001 Lippincott Williams & Wilkins.