Dissolution, cyclodextrin-enhanced solubilization, and mass removal of an ideal multicomponent organic liquid
Dissolution, cyclodextrin-enhanced solubilization, and mass removal of an ideal multicomponent organic liquid
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DOI：
10.1016/j.jconhyd.2009.01.002
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发表时间：
2009-04-15
影响因子：
3.6
通讯作者：
Brusseau, Mark L.
中科院分区：
文献类型：
--
作者：
Carroll, Kenneth C.;Brusseau, Mark L.
通过实验室实验和数学建模研究了羟丙基-β-环糊精（HPCD）溶液对单组分和三组分有机液体溶解的影响。批处理实验的结果表明，HPCD增强的有机液体混合物的溶解是理想的（可描述使用拉乌尔定律），并且溶解增强因子是独立的混合物组合物。将HPCD溶液添加到含有残余饱和有机液体的柱中，增强了混合物中所有三种化合物的溶解和去除。柱实验和数学建模的结果表明，增溶是理想的水和环糊精冲洗。同时，质量通量减少与质量去除行为是理想的所有实验。相对于水冲洗，由于溶解度和浓度梯度增强，HPCD增溶的传质增加。有机-液体组合物没有显著影响传质系数，并且对于每种化合物，无论是作为单一组分还是混合物存在，在HPCD溶解期间的质量去除分数行为几乎相同。此外，单组分和多组分混合物的水溶液和HPCD增溶的传质系数在通过溶解度增强因子归一化后没有统计学差异。(C)2009爱思唯尔有限公司版权所有。
Laboratory experiments and mathematical modeling were conducted to examine the influence of a hydroxypropyl-beta-cyclodextrin (HPCD) solution on the dissolution of single- and three-component organic liquids. The results of batch experiments showed that HPCD-enhanced solubilization of the organic-liquid mixtures was ideal (describable using Raoult's Law), and that solubilization-enhancement factors were independent of mixture composition. Addition of the HPCD solution to columns containing residual saturations of the organic liquid enhanced the dissolution and removal of all three compounds in the mixture. The results of the column experiments and mathematical modeling suggest that solubilization was ideal for both water and cyclodextrin flushing. Concomitantly, the mass-flux reduction versus mass removal behavior was ideal for all experiments. Mass transfer was increased for HPCD solubilization relative to the water flushing due to solubility and concentration-gradient enhancement. Organic-liquid composition did not significantly impact mass transfer coefficients, and fractional mass removal behavior during HPCD solubilization was nearly identical for each compound whether present as a single component or in a mixture. Additionally, mass transfer coefficients for aqueous and HPCD solubilization for single and multicomponent mixtures were not statistically different upon normalizing by the solubility enhancement factor. (C) 2009 Elsevier B.V. All rights reserved.