Biomimetic seleninates and selenonates
Biomimetic seleninates and selenonates
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DOI：
10.1021/ja8034448
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发表时间：
2008-07-23
影响因子：
15
通讯作者：
Knapp, Spencer
中科院分区：
文献类型：
--
作者：
Abdo, Mohannad;Knapp, Spencer
报道了通过相应的硒酯的DMDO氧化合成各种吡喃糖、核苷-、（氨基酸）-和多羟基的硒酸和硒酸，以及硒酸盐和硒酸盐官能团与生物亲核基团（巯基、吲哚、苯酚、咪唑）的一些不寻常的偶联反应。羧酰胺），存在于蛋白质和酶活性位点中。
The synthesis of a variety of pyranose, nucleoside-, (amino acid)-, and polyhydric-based seleninic and selenonic acids by DMDO oxidation of the corresponding selenoesters is reported, as well as some unusual coupling reactions of the seleninate and selenonate functionality with biological nucleophilic groups (sulfhydryl, indole, phenol, imidazole. carboxamide) that are found in proteins and enzyme active sites.