Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression.
Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression.
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DOI：
10.1016/0163-7258(88)90051-4
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发表时间：
1988
影响因子：
13.5
通讯作者：
D. Grdina;W. Guilford;C. Sigdestad;C. Giometti
中科院分区：
文献类型：
--
作者：
D. Grdina;W. Guilford;C. Sigdestad;C. Giometti
研究硫代磷酸酯药物在癌症治疗中的应用的动力源于 Yuhas 和 Storer (1969) 的早期观察，即与肿瘤组织相比，这些药物可能对正常组织有不同的保护作用。最近的报告表明，这些药物可能在癌症问题上发挥更广泛的作用，特别是在癌症预防领域。 Milas 等人 (1984) 最初观察到 S-2 (3-氨基丙氨基) 乙基硫代磷酸 (WR-2721, ethiofos) 可显着保护啮齿类动物免受辐射诱导肿瘤的影响，随后文献中出现了一系列描述抗诱变剂的报道 (Grdina 等人，1985a；Nagy 等人，1986；Nagy 和 Grdina，1986)， WR-2721 及其相应的游离硫醇 2-(3-氨基丙氨基)乙硫醇 (WR-1065) 具有抗转化作用（Hill 等，1986）和抗癌特性（Grdina 等，1985b）。这些研究有助于激发人们对表征受辐射影响的选定分子和细胞终点的强烈兴趣，例如 DNA 损伤和修复、对蛋白质的影响以及细胞周期进展。
The impetus for investigating the application of phosphorylthioate drugs for use in cancer therapy arose from the early observation by Yuhas and Storer (1969) that these drugs might differentially protect normal as compared to tumor tissue. Recent reports now suggest that these agents may have a more general role with respect to the cancer problem, especially in the area of cancer prevention. Following the initial observation by Milas et al.(1984) that S-2 (3-aminopropylamino) ethylphosphorothioic acid (WR-2721, ethiofos) significantly protected rodents against the induction of tumors by irradiation, a series of reports have appeared in the literature that describe the antimutagenic (Grdina et al., 1985a; Nagy et al., 1986; Nagy and Grdina, 1986), antitransformation (Hill et al., 1986), and the anticarcinogenic properties (Grdina et al., 1985b) of WR-2721 and its corresponding free thiol 2-(3-aminopropylamino) ethanethiol (WR-1065). These studies have helped to stimulate a strong interest in characterizing selected molecular and cellular end points affected by radiation such as DNA damage and repair, effects on proteins, and cell-cycle progression.