THE MOUSE SALIVARY ANDROGEN-BINDING PROTEIN (ABP) ALPHA-SUBUNIT CLOSELY RESEMBLES CHAIN-1 OF THE CAT ALLERGEN FEL DI
THE MOUSE SALIVARY ANDROGEN-BINDING PROTEIN (ABP) ALPHA-SUBUNIT CLOSELY RESEMBLES CHAIN-1 OF THE CAT ALLERGEN FEL DI
复制标题
DOI：
10.1007/bf00555830
复制
发表时间：
1994-08-01
影响因子：
2.4
通讯作者：
KARN, RC
中科院分区：
文献类型：
--
作者：
KARN, RC
雄激素结合蛋白（ABP）存在于多种啮齿动物的唾液中，并且已经提出ABP在性别和/或亚种识别中起作用（Karn和Dlouhy，J.赫雷德. 82，453，1991）。这是一份小鼠唾液ABP α亚基与猫过敏原Fel dI链1（50%同一性）以及与Fel dI链1具有同一性的其他两种蛋白质（兔子宫珠蛋白（与ABP α具有27%同一性）和人肺Clara 10（与ABP α具有27%同一性）之间具有显著同一性的报告。小鼠ABP α亚基的二级结构预测是一个非常好的拟合与兔子宫珠蛋白，与小鼠ABP的结合类固醇的能力共享的蛋白质的X-射线晶体学测定的二级结构。猫的唾液、皮脂腺和毛皮中含有Fel dI。其功能尚不清楚，但已提出其参与保护干燥上皮，类似于子宫珠蛋白保护湿上皮。因为老鼠和猫一样，会舔自己和彼此，所以用ABP覆盖它们的皮毛可能是这种或那种生物功能的一部分。
Androgen-binding protein (ABP) is found in the salivas of a wide variety of rodents and it has been proposed that ABP functions in sex and/or subspecies recognition (Karn and Dlouhy, J. Hered. 82, 453, 1991). This is a report of significant identity between the alpha subunit of mouse salivary ABP and Chain 1 of cat allergen Fel dI (50% identity, as well as with two other proteins that share identity with Chain 1 of Fel dI, rabbit uteroglobin (27% identity with ABP alpha) and human lung Clara 10 (27% identity with ABP alpha). The secondary structure predicted for the mouse ABP alpha subunit is a very good fit with the secondary structure determined by X-ray crystallography for rabbit uteroglobin, a protein that shares with mouse ABP the capability of binding steroid. Fel dI is found in cat saliva, sebaceous glands, and pelt. Its function is not known but it has been proposed to be involved in protecting dry epithelia, a parallel to uteroglobin protecting wet epithelia. Since mice, like cats, lick themselves and each other extensively, coating their pelts with ABP may be part of this or another biological function.