Cardiogenic differentiation and transdifferentiation of progenitor cells.
Cardiogenic differentiation and transdifferentiation of progenitor cells.
复制标题
DOI：
10.1161/circresaha.108.180588
复制
发表时间：
2008-11-07
影响因子：
20.1
通讯作者：
Laflamme MA
中科院分区：
文献类型：
--
作者：
Reinecke H;Minami E;Zhu WZ;Laflamme MA
近年来，细胞移植作为一种保留甚至恢复梗塞心脏收缩功能的新方法引起了极大的兴趣。典型的人类梗塞涉及约十亿个心肌细胞的损失，因此许多研究人员试图识别具有分化成定向心肌细胞并重新填充损失心肌的能力的内源或外源干细胞。这些努力的结果是，数十种干细胞类型已被报道具有心脏潜力。这些包括多能胚胎干细胞以及驻留在骨髓、外周组织和心脏本身等隔室中的各种成体干细胞。据报道，其中一些心源性祖细胞通过内源性修复过程或通过临床前心脏损伤模型中的细胞移植来贡献替代肌肉。然而，对于许多干细胞类型的心脏分化的效率甚至现实存在相当大的分歧，使得这些问题成为该领域持续争议的根源。在这篇综述中，我们考虑了细胞命运图谱和建立心脏表型的方法，以及主要候选干细胞类型的心源性和再生潜力的证据的现状。
In recent years, cell transplantation has drawn tremendous interest as a novel approach to preserving or even restoring contractile function to infarcted hearts. A typical human infarct involves the loss of approximately one billion cardiomyocytes, and so many investigators have sought to identify endogenous or exogenous stem cells with the capacity to differentiate into committed cardiomyocytes and repopulate lost myocardium. As a result of these efforts, dozens of stem cell types have been reported to have cardiac potential. These include pluripotent embryonic stem cells as well various adult stem cells resident in compartments including bone marrow, peripheral tissues, and the heart itself. Some of these cardiogenic progenitors have been reported to contribute replacement muscle through endogenous reparative processes or via cell transplantation in preclinical cardiac injury models. However, considerable disagreement exists regarding the efficiency and even the reality of cardiac differentiation by many of these stem cell types, making these issues a continuing source of controversy in the field. In this review, we consider approaches to cell fate mapping and establishing the cardiac phenotype, as well as the current state of the evidence for the cardiogenic and regenerative potential of the major candidate stem cell types.