Molecular epidemiology of primary human cytomegalovirus infection in pregnant women and their families
Molecular epidemiology of primary human cytomegalovirus infection in pregnant women and their families
复制标题
DOI：
10.1002/jmv.21243
复制
发表时间：
2008-08-01
影响因子：
12.7
通讯作者：
Gerna, Giuseppe
中科院分区：
文献类型：
--
作者：
Revello, Maria Grazia;Campanini, Giulia;Gerna, Giuseppe
本文对29例原发性巨细胞病毒（HCMV）感染孕妇进行了HCMV感染来源的研究，比较了各家系中流行的HCMV毒株的UL 146、UL 144和UL 55基因部分序列。确定了13个家庭，其中孕妇，丈夫和/或孩子正在脱落HCMV。在其中三个家庭中，妇女和丈夫都患有伴随的原发性HCMV感染。UL 146、UL 144和UL 55基因的系统发育分析表明，在每个家族中传播的菌株是相同的，而来自不同家族的菌株似乎是不同的。然而，在不相关的菌株中偶尔观察到相同的UL 146、UL 144和UL 55 DNA序列。绝大多数孕妇的病毒来源是孩子而不是丈夫。UL 144基因多态性与宫内传播无相关性。
The source of human cytomegalovirus (HCMV) infection was investigated in 29 pregnant women with primary HCMV infection by comparing DNA sequences of UL146, UL144 and a portion of UL55 gene of HCMV strains circulating within each family. Thirteen families were identified in which the pregnant woman, the husband and/or a child were shedding HCMV. In three of these families, both the woman and the husband suffered from a concomitant primary HCMV infection. Phylogenetic analysis of UL146, UL144, and UL55 genes indicated that strains circulating within each family were identical, whereas strains from different families appeared to be distinct. However, identical UL146, UL144, and UL55 DNA sequences were observed sporadically among unrelated strains. A child rather than the husband was the virus source for the great majority of pregnant women. No association was observed between UL144 polymorphisms and intrauterine transmission.