STAT heterodimers in immunity: A mixed message or a unique signal?
STAT heterodimers in immunity: A mixed message or a unique signal?
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DOI：
10.4161/jkst.23060
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Vignali DA
中科院分区：
文献类型：
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作者：
Delgoffe GM;Vignali DA
细胞因子信号对于产生强大的特异性免疫反应至关重要。这些信号通常通过规范的STAT同二聚体传输。然而，免疫细胞内细胞因子信号级联所利用的STAT分子数量有限，因此用于传递复杂信号的机制仍然难以捉摸。STAT蛋白的异源二聚化是信号在受体下游被修饰的一种潜在机制，并可能在决定特定细胞因子信号传导的目标方面发挥重要作用。在这篇综述中，我们讨论了我们目前对STAT异二聚体患病率的理解，它们是如何形成的，以及它们在体内的生理作用。
Cytokine signals are essential for generating a robust and specialized immune response. These signals are typically transmitted via canonical STAT homodimers. However, the number of STAT molecules utilized by cytokine signaling cascades within immune cells are limited, and so the mechanism used to deliver complex signals remains elusive. Heterodimerization of STAT proteins is one potential mechanism for signals to be modified downstream of the receptor and may play an important role in dictating the targets of specific cytokine signaling. In this review, we discuss our current understanding of the prevalence of STAT heterodimers, how they are formed and what their physiologic role may be in vivo.