NEUROLOGIC EVALUATION OF A POPULATION EXPOSED TO ARSENIC IN ALASKAN WELL WATER
NEUROLOGIC EVALUATION OF A POPULATION EXPOSED TO ARSENIC IN ALASKAN WELL WATER
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DOI：
10.1080/00039896.1983.10543990
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
COX, DH
中科院分区：
文献类型：
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作者：
KREISS, K;ZACK, MM;COX, DH
对147名井水砷暴露者进行了神经系统和神经传导研究。井水中的总As浓度范围为1至4781 μ g/l，尿中的总As浓度范围为6至4964 μ g/l; As摄入的计算指数范围为1至4521 μ g/天。没有剂量-反应关系之间存在的摄入和症状或物理结果与周围神经病变兼容。6例有感觉神经病变症状或体征的患者中有5例神经传导速度正常。13例砷摄入量升高但无神经病变体征或症状的患者有1个或多个神经传导速度异常。然而，砷摄入量与神经传导速度之间不存在剂量-反应关系。显然，在阿拉斯加社区发现的浓度下，从井水中摄入砷不会导致临床或亚临床神经病变。
Neurologic and nerve conduction studies were performed on 147 persons exposed to As from well water. Total As concentrations in well water ranged from 1 to 4781 .mu.g/l and from 6 to 4964 .mu.g/l in urine; a calculated index of As ingestion ranged from 1 to 4521 .mu.g/day. No dose-response relationship existed between As ingestion and symptoms or physical findings compatible with peripheral neuropathy. Five of 6 persons with symptoms or physical findings suggestive of sensory neuropathy had normal nerve conduction velocities. Thirteen persons with elevated As ingestion, but no signs or symptoms of neuropathy had 1 or more abnormal nerve conduction velocities. No dose-response relationship, however, existed between As ingestion and nerve conduction velocities. Evidently, As ingestion from well water at the concentrations found in this Alaskan community did not result in clinical or subclinical neuropathy.