Taking cues from the extracellular matrix to design bone-mimetic regenerative scaffolds.
Taking cues from the extracellular matrix to design bone-mimetic regenerative scaffolds.
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DOI：
10.1016/j.matbio.2016.02.011
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Bellis SL
中科院分区：
文献类型：
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作者：
Curry AS;Pensa NW;Barlow AM;Bellis SL
在骨损伤和骨缺陷的临床治疗中，持续需要可以替代自体骨移植物的有效材料。近年来，研究工作已经从关注惰性生物材料转向支持模拟天然骨细胞外基质（ECM）的生物化学和结构的支架。预期这种支架将与宿主组织整合并积极促进骨愈合。为了进一步增强骨移植替代物的骨诱导性，正在用一系列生长因子（GF）工程化ECM模拟支架。用于产生GF修饰的支架的技术通常受到调节内源性ECM和GF之间的关联的自然过程的启发。这篇综述的目的是总结研究集中在再生支架的发展，复制的基本胶原-羟基磷灰石结构的天然骨ECM，和这些支架的功能化与GF刺激成骨的关键事件。
There is an ongoing need for effective materials that can replace autologous bone grafts in the clinical treatment of bone injuries and deficiencies. In recent years, research efforts have shifted away from a focus on inert biomaterials to favor scaffolds that mimic the biochemistry and structure of the native bone extracellular matrix (ECM). The expectation is that such scaffolds will integrate with host tissue and actively promote osseous healing. To further enhance the osteoinductivity of bone graft substitutes, ECM-mimetic scaffolds are being engineered with a range of growth factors (GFs). The technologies used to generate GF-modified scaffolds are often inspired by natural processes that regulate the association between endogenous ECMs and GFs. The purpose of this review is to summarize research centered on the development of regenerative scaffolds that replicate the fundamental collagen-hydroxyapatite structure of native bone ECM, and the functionalization of these scaffolds with GFs that stimulate critical events in osteogenesis.