Complanadine B, obscurumines A and B, new alkaloids from two species of Lycopodium
Complanadine B, obscurumines A and B, new alkaloids from two species of Lycopodium
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DOI：
10.1016/j.tet.2005.01.011
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发表时间：
2005-02-21
期刊：
影响因子：
2.1
通讯作者：
Kobayashi, J
中科院分区：
文献类型：
--
作者：
Morita, H;Ishiuchi, K;Kobayashi, J
从球状苔藓石蒜和L中分得一个新的C16N2型生物碱--石杉碱B(1)和两个新的C16N型生物碱--暗色碱A(2)和B(3)。1-3的结构和立体化学结构通过2D核磁共振波谱和化学转化相结合的方法得到确证。从人脑星形细胞瘤细胞中分离到与1一起诱导神经营养因子分泌的康普拉定A(4)。(C)2005爱思唯尔有限公司。保留所有权利。
A new dirtier of C16N2 type alkaloid, complanadine B (1), and two new C16N type alkaloids, obscurumines A (2) and B (3), have been isolated from the club moss Lycopodium complanatum and L obscurum, respectively. The structures and stereochemistry of 1-3 were elucidated by combination of 2D NMR spectra and chemical transformation. Complanadine A (4) isolated together with 1 induced secretion of neurotrophic factors from human astrocytoma cells. (C) 2005 Elsevier Ltd. All rights reserved.