Incidence of cutaneous T-Cell lymphoma in the United States, 1973-2002
Incidence of cutaneous T-Cell lymphoma in the United States, 1973-2002
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DOI：
10.1001/archderm.143.7.854
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发表时间：
2007-07-01
影响因子：
--
通讯作者：
Weinstock, Martin A.
中科院分区：
文献类型：
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作者：
Criscione, Vincent D.;Weinstock, Martin A.
目的：描述美国皮肤 T 细胞淋巴瘤 (CTCL) 的发病趋势。设计：基于人群的研究。背景：数据从 1973 年至 2002 年美国国家癌症研究所监测、流行病学和最终结果 (SEER) 计划的 13 个基于人群的癌症登记处获得。参与者：1973 年至 2002 年期间总共确定了 4783 例 CTCL 病例。 2002.主要结果指标：CTCL 的诊断。结果：按年龄调整的 CTCL 年总体发病率为每百万人 6.4 例。在研究期间，年发病率每十年增加 2.9 x 10(-6)。黑人(9.0 x 10(-6))的发病率高于白人(6.1 x 10(-6))，男性(8.7 x 10(-6))的发病率高于女性(4.6 x 10(-6))。发病率的种族差异随着年龄的增长而减小，而性别差异则随着年龄的增长而增大，并随着时间的推移而减小。发现发病率存在显着的地理差异。发病率与医生密度高、家庭收入高、拥有学士学位或更高学历的人口比例高以及房屋价值高有关。国际肿瘤学疾病分类 (ICD-O) 形态学定义的变化导致 CTCL 病例在特定亚分类中重新分布。结论：CTCL 发病率持续大幅上升，但这种上升的原因尚不清楚。发病率的种族、民族、性别和地理差异可能具有重要的病因学意义。 ICD-O 定义的变化使得评估 CTCL 子分类（例如蕈样肉芽肿）的发病趋势变得困难。此外，这些变化导致产生了不明确的组织学代码，这可能导致编码错误。这些错误以及缺乏独立验证是我们研究的局限性。使用基于人群的数据进行流行病学调查对于更好地了解这种疾病非常重要。
Objective: To describe incidence trends for cutaneous T-cell lymphoma (CTCL) in the United States.Design: Population-based study.Setting: Data were obtained from 13 population-based cancer registries of the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute from 1973 through 2002.Participants: A total of 4783 cases of CTCL were identified for the period 1973 through 2002.Main Outcome Measure: Diagnosis of CTCL.Results: The overall annual age-adjusted incidence of CTCL was 6.4 per million persons. Annual incidence increased by 2.9 x 10(-6)per decade over the study period. Incidence was higher among blacks (9.0 x 10(-6)) than among whites (6.1 x 10(-6)) and was higher among men (8.7 x 10(-6)) than among women (4.6 x 10(-6)). The racial differences in incidence decreased with age, while the sex differences increased with age and decreased over time. Substantial geographic variation in incidence was found. Incidence was correlated with high physician density, high family income, high percentage of population with a bachelor's degree or higher, and high home values. Changes in International Classification of Diseases for Oncology (ICD-O) morphologic definitions have resulted in the redistribution of the cases of CTCL among specific subclassifications.Conclusions: The continued rise in incidence of CTCL is substantial, and the cause of this increase is unknown. The racial, ethnic, sex, and geographic differences in incidence may be of etiologic importance. Changes in ICD-O definitions have made it difficult to evaluate incidence trends for subclassifications of CTCL such as mycosis fungoides. In addition, these changes resulted in the creation of ambiguous histologic codes, which may have caused coding errors. These errors along with the lack of independent verification are limitations of our study. An epidemiological investigation using population-based data is important to better understand this disorder.