Continued complete remission without systemic therapy for isolated testicular relapse after bone marrow transplantation in a boy with acute lymphoblastic leukemia
Continued complete remission without systemic therapy for isolated testicular relapse after bone marrow transplantation in a boy with acute lymphoblastic leukemia
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DOI：
10.1111/j.1399-3046.2008.01023.x
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发表时间：
2009-09
影响因子：
1.3
通讯作者：
Y. Kodama;Y. Okamoto;O. Ijichi;Y. Shinkoda;T. Nishikawa;T. Tanabe;T. Yoshioka;Y. Tashiro;H. Mougi;Y. Kawano
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文献类型：
--
作者：
Y. Kodama;Y. Okamoto;O. Ijichi;Y. Shinkoda;T. Nishikawa;T. Tanabe;T. Yoshioka;Y. Tashiro;H. Mougi;Y. Kawano
翻译后摘要：ITR骨髓移植后的情况下，急性淋巴细胞白血病是相对罕见的。骨髓移植后ITR的治疗通常包括局部放疗、睾丸切除术和全身化疗的组合。然而，这些模式的有效性尚未确定。放疗和全身化疗（包括第二次移植）均会导致额外的毒性。在这份报告中，我们描述了一个男孩ITR 91个月后骨髓移植谁一直保持在完全缓解超过两年后，单侧睾丸切除术。我们没有对该患者进行全身化疗，因为他的ITR发展得很晚。我们的经验表明，单纯睾丸切除术是BMT后极晚期ITR的合理选择。
Abstract: ITR after BMT in cases of acute lymphoblastic leukemia is relatively rare. Treatment for ITR after BMT generally consists of a combination of local irradiation, orchiectomy, and systemic chemotherapy. However, the effectiveness of these modalities has not been established. Both irradiation and systemic chemotherapy including a second transplantation would result in additional toxicity. In this report we describe a boy with ITR 91 months after BMT who has remained in complete remission more than two yr after a unilateral orchiectomy. We did not treat this patient with systemic chemotherapy, as his ITR developed very late. Our experience suggests that orchiectomy alone is a reasonable option for very late ITR after BMT.