Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants
Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants
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DOI：
10.3945/ajcn.114.095026
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发表时间：
2015-01-01
影响因子：
7.1
通讯作者：
Ordovas, Jose M.
中科院分区：
文献类型：
--
作者：
Dashti, Hassan S.;Follis, Jack L.;Ordovas, Jose M.
背景：睡眠时间短与肥胖、高血压、糖尿病和心血管疾病的风险增加有关。此外，人类昼夜节律运动输出周期Kaput（CLOCK）中常见的遗传变异显示出与胃饥饿素和总能量摄入的关联。目的：我们研究了习惯性睡眠时间、体重指数（BM）和大量营养素摄入之间的关联，并评估了CLOCK变异是否改变了这些关联。设计：我们进行了逆方差加权，固定效应Meta分析调整后的睡眠时间与BMI和大量营养素摄入量占总能量的百分比的相关性，以及与CLOCK变体的相互作用，9项队列研究，包括来自基因组流行病学联盟心脏和衰老研究队列的多达14，906名欧洲后裔参与者。结果：我们观察到睡眠时间与较低BMI之间存在显着相关性（β +/- SE = 0.16 +/- 0.04，P < 0.0001）;然而，睡眠持续时间和相对大量营养素摄入之间的关联仅在年龄和性别分层分析中是明显的。我们观察到，年轻人的睡眠时间和较低的饱和脂肪酸摄入量之间存在显着关联，（20-64岁）成人（男性：0.11 +/-0.06%，P = 0.03;女性：0.10 +/-0.05%，P = 0.04）和低碳水化合物（-0.310.12%，P < 0.01），较高的总脂肪（0.18 +/-0.09%，P = 0.05），以及较高的PUFA（0.05 +/-0.02%，P = 0.02）摄入量。此外，观察到以下2个名义上显着的相互作用：睡眠时间和rs 12649507之间的PUFA摄入量和睡眠时间和rs6858749之间的蛋白质intake.Conclusions：我们的研究结果表明，较长的习惯性睡眠时间与较低的BMI和年龄和性别特定的有利的饮食行为。与睡眠时间短相关的特定常量营养素相对摄入量的差异至少可以部分解释先前报道的睡眠时间短与慢性代谢异常之间的关联。此外，肥胖相关的CLOCK变异体对睡眠时间和大量营养素摄入之间的关联的影响表明，较长的习惯性睡眠时间可以通过有利的饮食结构改善肥胖的遗传易感性。
Background: Short sleep duration has been associated with greater risks of obesity, hypertension, diabetes, and cardiovascular disease. Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake.Objectives: We examined associations between habitual sleep duration, body mass index (BM), and macronutrient intake and assessed whether CLOCK variants modify these associations.Design: We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations of sleep duration and BMI and macronutrient intake as percentages of total energy as well as interactions with CLOCK variants from 9 cohort studies including up to 14,906 participants of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.Results: We observed a significant association between sleep duration and lower BMI (beta +/- SE = 0.16 +/- 0.04, P < 0.0001) in the overall sample; however, associations between sleep duration and relative macronutrient intake were evident in age- and sex-stratified analyses only. We observed a significant association between sleep duration and lower saturated fatty acid intake in younger (aged 20-64 y) adults (men: 0.11 +/- 0.06%, P = 0.03; women: 0.10 +/- 0.05%, P = 0.04) and with lower carbohydrate (-0.31 0.12%, P < 0.01), higher total fat (0.18 +/- 0.09%, P = 0.05), and higher PUFA (0.05 +/- 0.02%, P = 0.02) intakes in older (aged 65-80 y) women. In addition, the following 2 nominally significant interactions were observed: between sleep duration and rs12649507 on PUFA intake and between sleep duration and rs6858749 on protein intake.Conclusions: Our results indicate that longer habitual sleep duration is associated with lower BMI and age- and sex-specific favorable dietary behaviors. Differences in the relative intake of specific macronutrients associated with short sleep duration could, at least in part, explain previously reported associations between short sleep duration and chronic metabolic abnormalities. In addition, the influence of obesity-associated CLOCK variants on the association between sleep duration and macronutrient intake suggests that longer habitual sleep duration could ameliorate the genetic predisposition to obesity via a favorable dietary profile.