BETA-ADRENERGIC-RECEPTOR DISTRIBUTION IN HUMAN AND RAT HIPPOCAMPAL-FORMATION - MARKED SPECIES-DIFFERENCES
BETA-ADRENERGIC-RECEPTOR DISTRIBUTION IN HUMAN AND RAT HIPPOCAMPAL-FORMATION - MARKED SPECIES-DIFFERENCES
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DOI：
10.1016/0006-8993(91)90752-h
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发表时间：
1991-10-04
期刊：
影响因子：
2.9
通讯作者：
STUMPF, WE
中科院分区：
文献类型：
--
作者：
DUNCAN, GE;LITTLE, KY;STUMPF, WE
通过 I-125-吲哚洛尔与组织切片的体外结合来评估大鼠和人海马结构中 β-肾上腺素能受体的拓扑结构。两个物种中β-肾上腺素能受体的分布以及β-1 和β-2 受体亚型的相对数量存在显着差异。在人类中，最高的受体密度存在于锥体细胞层和空隙分子层中。在大鼠海马体中，这些区域含有最低密度的 I-125-吲哚洛尔结合位点。在大鼠海马结构中，腹侧下托和内嗅皮层中β-肾上腺素能受体的密度最高。相比之下，在人类海马体中，下托和内嗅皮层的受体密度相对较低。 β-1-和β-2-选择性拮抗剂的竞争研究表明，β-2-肾上腺素能受体在人海马中占主导地位，而β-1-肾上腺素能受体在大鼠海马中占主导地位。观察到的明显的物种差异表明，与人类相比，大鼠海马对肾上腺素能药物的药理学反应以及去甲肾上腺素在调节海马功能中的作用可能有很大不同。
The topography of beta-adrenergic receptors in the rat and human hippocampal formation was assessed by in vitro binding of I-125-pindolol to tissue sections. Marked differences were found in the distribution of beta-adrenergic receptors and in the relative amounts of beta-1 and beta-2 receptor subtypes in the two species. In the human, the highest receptor densities were present in the pyramidal cell layer and in the stratum lacunosum-moleculare. In the rat hippocampus, those regions contained the lowest densities of I-125-pindolol binding sites. The highest densities of beta-adrenergic receptors in the rat hippocampal formation were found in the ventral subiculum and in the entorhinal cortex. In contrast, in the human hippocampus, the subiculum and entorhinal cortex contained relatively low densities of the receptors. Competition studies with beta-1-and beta-2-selective antagonists revealed that beta-2-adrenergic receptors predominate in the human hippocampus and beta-1-adrenergic receptors predominate in the rat hippocampus. The marked species differences observed suggest that the pharmacological responsivity of the hippocampus to adrenergic agents and the role of noradrenaline in regulation of hippocampal function could be very different in rats compared to humans.