Synthesis, characterization, and DNA binding of new water-soluble cyclopentadienyl ruthenium(II) complexes incorporating phosphines
Synthesis, characterization, and DNA binding of new water-soluble cyclopentadienyl ruthenium(II) complexes incorporating phosphines
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DOI：
10.1021/ic051053q
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发表时间：
2006-02-06
影响因子：
4.6
通讯作者：
García-Maroto, F
中科院分区：
文献类型：
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作者：
Romerosa, A;Campos-Malpartida, T;García-Maroto, F
合成了新的水溶性Ru(II)手性配合物[RuCpX(L)(L‘)](n+)(X=Cl，I.L=PPh3；L’=PtA，Mpta；L=L‘=Pta，Mpta)(Pta=1，3，5-三氮-7-磷金刚烷；Mpta=N-甲基-1，3，5-三氮-7-磷金刚烷)，并用核磁共振、红外光谱和元素分析进行了表征。还制备了盐Mpta(OSO2CF3)，并用光谱技术对其进行了全面表征。测定了[RuClCp(PPh3)(Pta)](2)、[RuCpl(PPh3)(Pta)](3)和[RuCpl(Mpta)(PPh3)](OSO2CF3)(9)的X射线晶体结构。用迁移率变化分析法研究了新的水溶性配合物与DNA的结合性质。而相应的含碘化合物[RuCpl(Pta)(2)](1)、[RuCpl(PPhAPTA)](3)、[RuCpl(Mpta)(2)](OSO2CF3)(2)(6)和[RuCpl(Mpta)(PPh3)](OSO2CF3)(9)不与DNA结合。
The new water-soluble ruthenium(II) chiral complexes [RuCpX(L)(L')](n+) (X = Cl, I. L = PPh3; L' = PTA, mPTA; L = L' = PTA, mPTA) (PTA = 1,3,5-triaza-7-phosphaadamantane; mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane) have been synthesized and characterized by NMR and IR spectroscopy and elemental analysis. The salt mPTA(OSO2CF3) was also prepared and fully characterized by spectroscopic techniques. X-ray crystal structures of [RuClCp(PPh3)(PTA)] (2), [RuCpl(PPh3)(PTA)] (3), and [RuCpl(mPTA) (PPh3)](OSO2CF3) (9) have been determined. The binding properties toward DNA of the new hydrosoluble complexes have been studied using the mobility shift assay. The ruthenium chloride complexes interact with DNA depending on the hydrosoluble phosphine bonded to the metal, while the corresponding compounds with iodide, [RuCpl(PTA)(2)] (1), [RuCpl(PPhAPTA)] (3), [RuCpl(mPTA)(2)](OSO2CF3)(2) (6), and [RuCpl(mPTA)(PPh3)](OSO2CF3) (9), do not bind to DNA.