Requirements for Diagnosis of Malaria at Different Levels of the Laboratory Network in Africa
Requirements for Diagnosis of Malaria at Different Levels of the Laboratory Network in Africa
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DOI：
10.1309/ajcpvx71bxwovwby
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发表时间：
2009-06-01
影响因子：
3.5
通讯作者：
Long, Earl G.
中科院分区：
文献类型：
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作者：
Long, Earl G.
对廉价、可靠的抗疟药的抗药性迅速增加，有效药物的成本不断增加，以及临床诊断的低特异性，增加了对更可靠的疟疾诊断方法的需求。最常用和最可靠的仍然是染色血涂片的显微镜检查，但这种技术需要熟练的人员，精密仪器，最好是电源。显微镜检查的优点是使检查者能够确定感染的种类、阶段和密度。一种替代显微镜检查的方法是快速诊断试验（RDT），它使用标记的单克隆抗体来检测循环寄生虫抗原。这种检测最常用于检测恶性疟原虫感染，并以塑料盒形式提供。显微镜和RDT都应该在各级实验室服务中提供吗？在流行区，RDT可能是一种更实用的诊断方法，但在工作人员培训最少的外围实验室，RDT可能是一种更实用的诊断方法。
The rapid increase of resistance to cheap, reliable antimalarials, the increasing cost of effective drugs, and the low specificity of clinical diagnosis has increased the need for more reliable diagnostic methods for malaria. The most commonly used and most reliable remains microscopic examination of stained blood smears, but this technique requires skilled personnel, precision instruments, and ideally a source of electricity. Microscopy has the advantage of enabling the examiner to identify the species, stage, and density of an infection. An alternative to microscopy is the rapid diagnostic test (RDT), which uses a labeled monoclonal antibody to detect circulating parasitic antigens. This lest is most commonly used to detect Plasmodium falciparum infections and is available in a plastic cassette formal. Both microscopy and RDTs should be available at all levels of laboratory service it? endemic areas, but in peripheral laboratories with minimally trained staff the RDT may be a more practical diagnostic method.