High cognitive function of an ALS patient in the totally locked-in state
High cognitive function of an ALS patient in the totally locked-in state
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DOI：
10.1016/j.neulet.2008.01.046
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发表时间：
2008-04-18
影响因子：
2.5
通讯作者：
Yoro, Takeshi
中科院分区：
文献类型：
--
作者：
Fuchino, Yutaka;Nagao, Masahiro;Yoro, Takeshi
肌萎缩侧索硬化症(ALS)是一种以上下运动神经元进行性变性为特征的运动神经元疾病。肌萎缩侧索硬化症患者逐渐失去控制自主运动的能力，偶尔进入完全锁定状态(TLS)，在这种状态下，他们无法移动身体的任何部分，包括眼睛。在这项研究中，我们使用光学地形图来阐明73岁的ALS患者在TLS中的运动系统的保存能力和重组，光学地形图是近红外光谱的一种新的扩展。患者完成了四项认知任务：双耳听、隐蔽歌唱、词语流畅性和运动想象。双侧前额叶和双侧感觉运动区在两种语言相关任务(二分听和单词流利性)中被激活，右侧前额和双侧感觉运动区在隐蔽歌唱任务中被激活，右侧前额和背运动区在运动想象任务中被激活。在运动想象任务中，未观察到对侧感觉运动的激活。这些结果表明，在TLS的ALS患者中，认知功能可以被保留，感觉运动区起着重要的作用。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of upper and lower motor neurons. Patients with ALS progressively lose their ability to control voluntary movements and occasionally enter the totally locked-in state (TLS), in which they cannot move any part of their bodies including the eyes. In this study, we clarified the preserved abilities and reorganization of the motor system of a 73-year-old patient with ALS in the TLS using optical topography, a recently developed extension of near-infrared spectroscopy. The patient performed four cognitive tasks: dichotic listening, covert singing, word fluency, and motor imagery. The bilateral prefrontal and bilateral sensorimotor areas were activated during the two language-related tasks (dichotic listening task and the word fluency), the right prefrontal and sensorimotor areas during the covert singing task, and the right prefrontal and dorsal sensorimotor areas during the motor imagery task. Contralateral sensorimotor activation was not observed in the motor imagery task. These results suggest that cognitive functions can be preserved in ALS in the TLS, with sensorimotor areas playing an important role. (c) 2008 Elsevier Ireland Ltd. All rights reserved.