TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity
TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity
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DOI：
10.1016/s0165-5728(02)00368-5
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发表时间：
2002-12-01
影响因子：
3.3
通讯作者：
Boucraut, J
中科院分区：
文献类型：
--
作者：
Desplat-Jégo, S;Varriale, S;Boucraut, J
TWINE是一个新的肿瘤坏死因子家族成员，通过新近发现的Fn14受体对不同类型的细胞具有促炎和增殖作用。分析小鼠小胶质细胞和星形胶质细胞上TWEAM的表达。两种类型的细胞都表达TWEY mRNA。星形胶质细胞表达Fn14，并在rTWEAK存在下增殖。在正常中枢神经系统有TWEY基因的表达，而在EAE过程中其在脊髓中的稳态水平升高。最后，在可溶性TWEY过表达的转基因小鼠中，EAE的严重程度得到了加强。这些结果支持了TWINE与中枢神经系统炎症有关的观点。(C)2002 Elsevier Science B.V.保留所有权利。
TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types express TWEAK mRNA. Astrocytes expressed Fn14 and proliferated in the presence of rTWEAK. TWEAK mRNA is expressed in normal CNS and its steady state level increases in spinal cord during EAE. Finally, EAE severity is enhanced in soluble TWEAK-overexpressing transgenic mice. These results support the contention that TWEAK is involved in CNS inflammation. (C) 2002 Elsevier Science B.V. All rights reserved.