Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France
Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France
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DOI：
10.1038/aja.2011.173
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发表时间：
2012-07-01
影响因子：
2.9
通讯作者：
Guichaoua, Marie-Roberte
中科院分区：
文献类型：
--
作者：
Geoffroy-Siraudin, Cendrine;Loundou, Anderson Dieudonne;Guichaoua, Marie-Roberte
1988年至2007年期间，在法国马赛大学医院生殖生物学实验室对10932例不育夫妇的男性伴侣的精液进行了分析，并对精子参数趋势进行了评价。禁欲3-6天后，收集精液样本。测量精液量、pH值、精子浓度、精子总数、活力和精子的详细形态。对整个人群和总计数正常（每次射精>= 4000万）的男性进行精子参数分析。整个人群表现出精子浓度（每年1.5%）、精子总数（每年1.6%）、总活力（每年0.4%）、快速活力（每年5.5%）和正常形态（每年2.2%）下降的趋势。在精子总数正常的样本组中，观察到精子质量随时间的变化趋势相同。我们的研究结果清楚地表明，在研究期间，这一人群的精液质量下降。亚洲男科学杂志（2012）14，584-590; doi：10.1038/aja.2011.173;在线发表于2012年4月23日
Semen from 10 932 male partners of infertile couples was analysed and sperm parameter trends were evaluated at the Reproduction Biology Laboratory of the University Hospital of Marseille (France) between 1988 and 2007. After 3-6 days of abstinence, semen samples were collected. Measurements of seminal fluid volume, pH, sperm concentration, total sperm count, motility and detailed morphology of spermatozoa were performed. Sperm parameters were analysed on the entire population and in men with normal total numeration (>= 40 million per ejaculate). The whole population demonstrated declining trends in sperm concentration (1.5% per year), total sperm count (1.6% per year), total motility (0.4% per year), rapid motility (5.5% per year) and normal morphology (2.2% per year). In the group of selected samples with total normal sperm count, the same trends of sperm quality deterioration with time were observed. Our results clearly indicate that the quality of semen decreased in this population over the study period. Asian Journal of Andrology (2012) 14, 584-590; doi:10.1038/aja.2011.173; published online 23 April 2012