ABSORPTION AND EXCRETION OF DRUGS. XX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (2). ABSORPTION FROM RAT SMALL INTESTINE.
ABSORPTION AND EXCRETION OF DRUGS. XX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (2). ABSORPTION FROM RAT SMALL INTESTINE.
复制标题
药物的吸收和排泄。
DOI：
10.1248/cpb.12.421
复制
发表时间：
1964
影响因子：
1.7
通讯作者：
K. Kakemi
中科院分区：
文献类型：
--
作者：
T. Koizumi;T. Arita;K. Kakemi
用17种磺胺类药物和5种N-4-乙酰衍生物在大鼠小肠进行在体再循环，测定非离子化药物的吸收率。提出的药物从大鼠胃吸收的动力学模型也解释了从大鼠小肠的吸收，尽管给出合适P的有机溶剂不同。
Rat small intestine was recirculated in situ with seventeen kinds of sulfonamide and five N4-acetyl derivatives, and absorption rate of the unionized drug was determined. The kinetical model proposed for the absorption of the drug from rat stomach also accounts for the absorption from rat small intestine, though the organic solvents that give suitable P are different.