Vaccines against human enteric bacterial pathogens
Vaccines against human enteric bacterial pathogens
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DOI：
10.1093/bmb/62.1.113
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发表时间：
2002-01-01
影响因子：
6.7
通讯作者：
Clare, S
中科院分区：
文献类型：
--
作者：
Dougan, G;Huett, A;Clare, S
针对肠道细菌病原体的疫苗的开发提出了挑战，因为大量病原体能够引起疾病，并且需要诱导在肠道中有效的免疫。基于口服或注射的活或非活抗原的新一代肠道疫苗正在评估的早期阶段进入临床。然而，在这些疫苗到达普通人群之前，必须克服相当大的技术障碍。
The development of vaccines against enteric bacterial pathogens presents a challenge because of the large number of pathogens capable of causing disease and the requirement to induce immunity that is effective in the gut. A new generation of enteric vaccines based either on live or non-living antigens delivered orally or by injection are reaching the clinic in the early phases of evaluation. However, considerable technical barriers have to be overcome before these vaccines reach the general population.