Human Umbilical Cord Mesenchymal Stem Cells Suppress Systemic Lupus Erythematosus Lesions by Rebalancing CD4+/CD8+ Cell Population
Human Umbilical Cord Mesenchymal Stem Cells Suppress Systemic Lupus Erythematosus Lesions by Rebalancing CD4+/CD8+ Cell Population
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DOI：
10.17352/sscrt.000003
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发表时间：
2015-08
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通讯作者：
Chan Li;Hongfang Ju;Qiongshu Li;Xin Zhou;Xiaoping Zeng;Yixin He;G. Zeng;Jia Liu;Chun-feng Wu;Tenglong Yan;Wei Li;J. Cui;Xiang Hu;Ji-fan Hu;Tao Li
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文献类型：
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作者：
Chan Li;Hongfang Ju;Qiongshu Li;Xin Zhou;Xiaoping Zeng;Yixin He;G. Zeng;Jia Liu;Chun-feng Wu;Tenglong Yan;Wei Li;J. Cui;Xiang Hu;Ji-fan Hu;Tao Li
尽管在系统性红斑狼疮（SLE）的治疗方面取得了相当大的进展，但仍然需要开发具有改善的功效和更低的副作用的新的治疗方法。在此，我们探讨了人脐带间充质干细胞（hUCMSCs）作为一种有前途的治疗系统性红斑狼疮诱导的伴刀豆球蛋白A激活的脾淋巴细胞在BALB/c小鼠。
Despite considerable advances in the treatment for systemic lupus erythematosus (SLE), there is still an unmet need to develop novel therapeutic approaches with improved efficacy and lower side effects. Here we explore human umbilical cord-derived mesenchymal stem cells (hUCMSCs) as a promising treatment for SLE induced by concanavalin A-activated spleno-lymphocyte in BALB/c mice.