MoS2 Field-Effect Transistor for Next-Generation Label-Free Biosensors
MoS2 Field-Effect Transistor for Next-Generation Label-Free Biosensors
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DOI：
10.1021/nn5009148
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发表时间：
2014-04-01
期刊：
影响因子：
17.1
通讯作者：
Banerjee, Kaustav
中科院分区：
文献类型：
--
作者：
Sarkar, Deblina;Liu, Wei;Banerjee, Kaustav
基于场效应晶体管（FET）的生物传感器由于其快速、廉价和无标记的检测特性而备受关注。虽然基于体3D结构的FET生物传感器的低灵敏度已经通过使用1D结构（纳米管/纳米线）来克服，但后者面临着严峻的制造挑战，从而损害了它们的实际应用。本文介绍并展示了基于二硫化钼（MoS 2）的场效应晶体管生物传感器，由于其二维原子层状结构，它提供了极高的灵敏度，同时提供了易于图案化和器件制造的能力。一种基于二硫化钼的pH传感器实现高达713的灵敏度为1个单位的pH值变化沿着与有效的操作在较宽的pH值范围（3-9）被证明。即使在100飞摩尔浓度下，也实现了超灵敏度和特异性蛋白质感测，灵敏度为196。虽然石墨烯也是一种2D材料，但我们在这里表明，它无法与基于MoS 2的FET生物传感器竞争，后者的灵敏度超过基于石墨烯的74倍。此外，我们通过理论分析建立了MoS 2对于生物传感器设备缩放非常有利，而不影响其灵敏度，这有利于单分子检测。此外，MoS 2具有高度灵活和透明的性质，可以在先进的诊断和医疗假体方面提供新的机会。这种独特的融合所需的属性使二硫化钼下一代低成本生物传感器的一个非常有潜力的候选人。
Biosensors based on field-effect transistors (FETs) have attracted much attention, as they offer rapid, inexpensive, and label-free detection. While the low sensitivity of FET biosensors based on bulk 3D structures has been overcome by using 1D structures (nanotubes/nanowires), the latter face severe fabrication challenges, impairing their practical applications. in this paper, we introduce and demonstrate FET biosensors based on molybdenum disulfide (MoS2), which provides extremely high sensitivity and at the same time offers easy patternability and device fabrication, due to its 2D atomically layered structure. A MoS2-based pH sensor achieving sensitivity as high as 713 for a pH change by 1 unit along with efficient operation over a wide pH range (3-9) is demonstrated. Ultrasensitive and specific protein sensing is also achieved with a sensitivity of 196 even at 100 femtomolar concentration. While graphene is also a 2D material, we show here that it cannot compete with a MoS2-based FET biosensor, which surpasses the sensitivity of that based on graphene by more than 74-fold. Moreover, we establish through theoretical analysis that MoS2 is greatly advantageous for biosensor device scaling without compromising its sensitivity, which is beneficial for single molecular detection. Furthermore, MoS2, with its highly flexible and transparent nature, can offer new opportunities In advanced diagnostics and medical prostheses. This unique fusion of desirable properties makes MoS2 a highly potential candidate for next-generation low-cost biosensors.