Aurora Mitochondrialis drives fission during mitosis.
Aurora Mitochondrialis drives fission during mitosis.
复制标题
DOI：
10.1016/j.devcel.2011.08.020
复制
发表时间：
2011-09
影响因子：
11.8
通讯作者：
A. Maia;H. Maiato
中科院分区：
文献类型：
--
作者：
A. Maia;H. Maiato
在每个细胞分裂周期中，线粒体通过生长和分裂进行增殖。最近，Kashatus等（2011）报道了Aurora A激酶调节小GTPase RalA介导线粒体裂变。这项工作阐明了哺乳动物线粒体遗传背后的分子机制，并扩展了一个关键的有丝分裂调节因子的功能库。
Mitochondria proliferate by growth and partition during every cell-division cycle. Recently, Kashatus et al. (2011) reported that Aurora A kinase regulates the small GTPase RalA to mediate mitochondrial fission. This work illuminates the molecular mechanism behind mitochondrial inheritance in mammals and extends the functional repertoire of a key mitotic regulator.