A highly selective and sensitive colorimetric and near-infrared fluorescent turn-on probe for rapid detection of palladium in drugs and living cells
A highly selective and sensitive colorimetric and near-infrared fluorescent turn-on probe for rapid detection of palladium in drugs and living cells
复制标题
一种高选择性和灵敏的比色和近红外荧光开启探针，用于快速检测药物和活细胞中的钯
DOI：
10.1016/j.snb.2017.11.099
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发表时间：
2018-04-01
影响因子：
8.4
通讯作者：
Feng, Guoqiang
中科院分区：
文献类型：
--
作者：
Xia, Qingfeng;Feng, Shumin;Feng, Guoqiang
由于钯物种的毒性和广泛使用，钯污染引起了广泛关注。因此，开发简便、有效的钯检测方法具有重要意义。本文基于Tsuji-Trost反应，开发了一种新的钯的比色和近红外（NIR）荧光探针。该探针可用于在温和条件下以高选择性和灵敏度检测水溶液（例如，在具有0- 20%DMSO的pH 7.4 PBS缓冲液中）中的钯，提供快速（2分钟内）和独特的双重比色和NIR荧光开启信号变化，检测限低至2.2 nM。用该探针制备了试纸条系统，可方便地进行钯的目视检测。此外，MTT实验表明该探针具有较低的细胞毒性，并成功应用于真实的药物样品和活细胞中钯的检测，表明该探针具有良好的应用前景。(c)2017爱思唯尔B. V.保留所有权利。
Palladium contamination has attracted widespread attention due to the toxicity and the wide use of palladium species. Consequently, development of convenient and effective methods for palladium detection is of great importance. Herein, a new colorimetric and near-infrared (NIR) fluorescent turn-on probe based on the Tsuji-Trost reaction for palladium was developed. This probe can be used to detect palladium in aqueous solution (for example, in pH 7.4 PBS buffer with 0-20% DMSO) under mild conditions with high selectivity and sensitivity, giving rapid (within 2 min) and distinct dual colorimetric and NIR fluorescent turn-on signal changes with a detection limit as low as 2.2 nM. A paper test strip system was prepared with this probe for a convenient visual detection of palladium. In addition, MTT assays showed that this probe has low cytotoxicity and detection of palladium in real drug samples and living cells was successfully applied with this probe, indicating this probe has a good application prospect. (c) 2017 Elsevier B.V. All rights reserved.