Optical coherence tomography detection of vulnerable plaques at high risk of developing acute coronary syndrome
Optical coherence tomography detection of vulnerable plaques at high risk of developing acute coronary syndrome
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DOI：
10.1093/ehjci/jeab028
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发表时间：
2021-02-23
影响因子：
6.2
通讯作者：
Akasaka, Takashi
中科院分区：
文献类型：
--
作者：
Kubo, Takashi;Ino, Yasushi;Akasaka, Takashi
目的光学相干断层扫描（OCT）检测急性冠脉综合征（ACS）高危斑块的能力尚不清楚。本研究的目的是通过OCT评估以富脂斑块（LRP）和薄帽纤维粥样硬化（TCFA）为特征的非罪魁祸首斑块与病变水平上随后ACS事件的风险之间的关系。方法和结果在1378例接受OCT的患者中，分析了3533个非罪魁祸首斑块是否存在LRP（最大脂质弧bb0 180度）和TCFA（最小纤维帽厚度< 65 μ m）。中位随访期为6年[四分位间距（IQR）： 5-9年]。72例ACS是由基线oct成像的非罪魁祸首斑块引起的，ACS更常与具有LRP和TCFA特征的脂质斑块相关，而非具有这些特征的脂质斑块[33% vs. 2%，风险比19.14(95%可信区间：11.74-31.20)，P
Aims The ability of optical coherence tomography (OCT) to detect plaques at high risk of developing acute coronary syndrome (ACS) remains unclear. The aim of this study was to evaluate the association between non-culprit plaques characterized as both lipid-rich plaque (LRP) and thin-cap fibroatheroma (TCFA) by OCT and the risk of subsequent ACS events at the lesion level.Methods and results In 1378 patients who underwent OCT, 3533 non-culprit plaques were analysed for the presence of LRP (maximum lipid arc > 180 degrees) and TCFA (minimum fibrous cap thickness < 65 mu m). The median follow-up period was 6 years [interquartile range (IQR): 5-9 years]. Seventy-two ACS arose from non-culprit plaques imaged by baseline OCT. ACS was more often associated with lipidic plaques that were characterized as both LRP and TCFA vs. lipidic plaques that did not have these characteristics [33% vs. 2%, hazard ratio 19.14 (95% confidence interval: 11.74-31.20), P