Atg1-independent induction of autophagy by the Drosophila Ulk3 homolog, ADUK.
Atg1-independent induction of autophagy by the Drosophila Ulk3 homolog, ADUK.
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DOI：
10.1111/febs.13906
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Neufeld TP
中科院分区：
文献类型：
--
作者：
Braden CR;Neufeld TP
Although canonical autophagy regulation requires a multi-protein complex centered on the Ser/Thr-kinase Atg1 (mammalian Ulk1/2), alternative signals can induce autophagy independently of Atg1 through unknown mechanisms. Here we identify the Drosophila Ulk3 ortholog, ADUK, as an Atg1-independent autophagy inducer. ADUK interacts with Atg1 complex members Atg13 and Fip200, and requires Atg13 but not Atg1 for autophagy induction. Loss of ADUK shortens adult lifespan and reduces the autophagic response to a chemical stressor, DMSO. However, ADUK is not required for autophagy induction by Atg1-dependent nutrient or developmental cues. Atg1 and ADUK/Ulk3 thus represent alternative catalytic components of a shared autophagy kinase complex. Atg1/Ulk1-independent autophagy has been previously reported, but the mechanisms remain elusive. Here we identify the Drosophila Ulk family kinase ADUK as an Ulk3 ortholog that can promote autophagy in the absence of Atg1, through interactions with FIP200 and Atg13. Despite sharing these factors with Atg1, ADUK is dispensable for starvation-induced autophagy, but is required for autophagy induction by chemical stress.
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