Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis.
Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis.
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维生素 D 缺乏与阿尔茨海默病和痴呆症的风险增加有关：荟萃分析的证据
DOI：
10.1186/s12937-015-0063-7
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发表时间：
2015-08-01
影响因子：
5.4
通讯作者：
Ji HF
中科院分区：
文献类型：
--
作者：
Shen L;Ji HF
近年来，维生素D水平与阿尔茨海默病（AD）和痴呆症之间的关系引起了越来越多的关注。本荟萃分析旨在评估维生素D缺乏与AD和痴呆风险之间的关系。直到2015年2月进行的文献检索确定了10个研究人群，并将其纳入meta分析。采用Stata软件包，采用随机效应模型计算合并风险比（rr）和95%置信区间（CI）。我们的荟萃分析结果显示，维生素D缺乏（25(OH)D水平< 50 nmol/L）的受试者与25(OH)D水平低于50 nmol/L的受试者相比，患AD的风险增加了21%。类似的分析还发现，缺乏维生素D的人患痴呆症的风险显著增加。没有证据表明在纳入的研究中存在显著的异质性。现有数据表明，较低的维生素D水平可能与患阿尔茨海默病和痴呆症的风险增加有关。需要更多的研究来进一步证实这种关联，并评估补充维生素D在预防AD和痴呆方面的有益作用。
In recent years, the associations between vitamin D status and Alzheimer’s disease (AD) and dementia have gained increasing interests. The present meta-analysis was designed to estimate the association between vitamin D deficiency and risk of developing AD and dementia. A literature search conducted until February 2015 identified 10 study populations, which were included in the meta-analysis. Pooled risk ratios (RRs) and 95 % confidence interval (CI) were calculated with a random-effect model using Stata software package. Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21 % compared with those possessing 25(OH)D level > 50 nmol/L. Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects. There is no evidence for significant heterogeneity among the included studies. Available data indicates that lower vitamin D status may be associated with increased risk of developing AD and dementia. More studies are needed to further confirm the associations and to evaluate the beneficial effects of vitamin D supplementation in preventing AD and dementia.