Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later
Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later
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DOI：
10.1016/j.jpeds.2007.09.010
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发表时间：
2008-02-01
影响因子：
5.1
通讯作者：
Glueck, Charles J.
中科院分区：
文献类型：
--
作者：
Morrison, John A.;Friedman, Lisa Aronson;Glueck, Charles J.
目的前瞻性研究儿童代谢综合征与成人代谢综合征和2型糖尿病（T2 DM）的关系，研究设计：采用美国国家心肺血液研究所（NationalHeartLungandBloodInstituteLipidResearchClinics，LRC）普林斯顿患病率研究（1973-1976）和普林斯顿随访研究（PSO 2000-2004）的资料。体重指数（BMI = kg/m2）被用于儿童肥胖的测量，因为LRC没有测量腰围。作为参与者，他们的父母的成人T2 DM状态通过参与者报告或空腹血糖>= 126 mg/dL获得。使用聚类样本的逻辑分析来预测成人代谢综合征和T2 DM，同时考虑队列中的同胞相关性。儿童代谢综合征，PFS的年龄，性别，种族，BMI百分位数的变化，父母的糖尿病史，儿童代谢综合征和父母的糖尿病的相互作用是解释variable.Results年龄范围从5到19岁的LRC和从30到48岁的PFS。儿童代谢综合征、父母糖尿病、随访时的年龄和年龄特异性BMI百分位数的变化是成年期代谢综合征的重要预测因子，儿童代谢综合征、随访时的年龄、黑人、和父母糖尿病是T2 DM的重要预测因素。老年儿童的代谢综合征和糖尿病家族史可以识别儿童成人代谢综合征和T2 DM的风险增加，允许这些结果的前瞻性一级预防。
Objective To prospectively assess the association of the metabolic syndrome in childhood with adult metabolic syndrome and type 2 diabetes mellitus (T2DM) 25 to 30 years later.Study design Data from the National Heart Lung and Blood Institute Lipid Research Clinics (LRC) Princeton Prevalence Study (1973-1976) and the Princeton Follow-up Study (PFS, 2000-2004) were used. Body mass index (BMI = kg/m(2)) was used he obesity measure in childhood because waist circumference was not measured at the LRC. The adult T2DM status of, as participants, I their parents was obtained by participant report or fasting blood glucose >= 126 mg/dL A logistic analysis for clustered samples was used to predict adult metabolic syndrome and T2DM, taking into account sibling correlations in the cohort. Pediatric metabolic syndrome, age at PFS, sex, race, change in BMI percentile, parental history of diabetes, and the interaction of pediatric metabolic syndrome and parental diabetes were explanatory variables.Results Ages ranged from 5 to 19 years in the LRC and from 30 to 48 years in the PFS. Pediatric metabolic syndrome, parental diabetes, age at follow-up, and change in age-specific BMI percentile were significant predictors of metabolic syndrome in adulthood, and Pediatric metabolic syndrome, age at follow-up, black race, and parental diabetes were significant predictors of T2DM.Conclusions Evaluating 5- to 19-year-old children for metabolic syndrome and family history of diabetes could identify children at increased risk of adult metabolic syndrome and T2DM, allowing prospective primary prevention of these outcomes.