Vascular endothelial growth factor signaling in development and disease
Vascular endothelial growth factor signaling in development and disease
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DOI：
10.1242/dev.151019
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发表时间：
2018-07-15
期刊：
影响因子：
4.6
通讯作者：
Alitalo, Kari
中科院分区：
文献类型：
--
作者：
Karaman, Sinem;Leppanen, Veli-Matti;Alitalo, Kari
血管内皮生长因子（VEGF）最为人所知的是它们参与协调血液和淋巴管系统的发育和维持。VEGF由多种细胞分泌，并且它们与内皮细胞中的其同源酪氨酸激酶VEGF受体（VEGF受体）结合以引发各种下游效应。近年来，在阐明血管内皮生长因子/血管内皮生长因子受体在血液和淋巴管系统中的不同信号传导功能方面取得了巨大进展。在这里，并在所附的海报，我们提出了VEGF/VEGFR途径的关键要素，并强调了经典和新发现的功能，血管和淋巴管的发展和病理的VEGF信号。
Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind to their cognate tyrosine kinase VEGF receptors (VEGFRs) in endothelial cells to elicit various downstream effects. In recent years, there has been tremendous progress in elucidating different VEGF/VEGFR signaling functions in both the blood and lymphatic vascular systems. Here, and in the accompanying poster, we present key elements of the VEGF/VEGFR pathway and highlight the classical and newly discovered functions of VEGF signaling in blood and lymphatic vessel development and pathology.