Sensitivity and specificity of the Distress Thermometer for depression in newly diagnosed breast cancer patients
Sensitivity and specificity of the Distress Thermometer for depression in newly diagnosed breast cancer patients
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DOI：
10.1002/pon.1289
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发表时间：
2008-06-01
期刊：
影响因子：
3.6
通讯作者：
Ahles, Tim A.
中科院分区：
文献类型：
--
作者：
Hegel, Mark T.;Collins, E. Dale;Ahles, Tim A.
导致严重的抑郁症发作。需要在肿瘤学环境中检测抑郁症的有效筛查方法。这项研究评估了单项遇险温度计(DT)的受试者工作特性(ROC)，用于检测新诊断的I-III期乳腺癌患者的抑郁情绪。方法：我们在综合乳腺癌计划中评估了321名患者(连续345名)的术前咨询时间。结果：抑郁组的DT评分(11分)显著高于非抑郁组(8.1分，4.4分)。在ROC分析中，相对于PHQ-9得出的抑郁症诊断，DT显示出很强的区分力，曲线下的面积为0.87。患者的年龄、文化程度、婚姻状况和疾病分期导致相似的手术特点。7分代表了检测抑郁的敏感度(0.81)和特异度(0.85)之间的最佳折衷。结论：相对于PHQ-9，单项DT在检测初诊乳腺癌患者抑郁方面的表现令人满意。以7分为临界值的DT具有最佳的敏感性和特异性。这些发现的力量表明，在进行积极的筛查之后，应该进行仔细的心理社会评估。版权所有(C)2007 John Wiley&Sons，Ltd.
precipitate an episode of major depressive disorder. Efficient screening methods for detecting depression in the oncology setting are needed. This study evaluated the receiver operating characteristics (ROC) of the single-item Distress Thermometer (DT) for detecting depression in women newly diagnosed with Stage I-III breast cancer.Methods: We assessed 321 patients (of 345 consecutive patients) at the time of their pre-surgical consultation at a Comprehensive Breast Cancer Program. Patients were administered the DT along with the Patient Health Questionnaire 9-Item Depression Module (PHQ-9) as a gold standard diagnostic assessment of depression status.Results: Mean DT scores (11-point scale, 0-10) were significantly higher for depressed versus non-depressed patients (8.1 versus 4.4). In ROC analyses the DT showed strong discriminatory power relative to the PHQ-9-derived diagnosis of depression, with an area under the curve of 0.87. Patient age, education, marital status and stage of disease resulted in similar operating characteristics. A score of 7 represented the optimal trade-off between sensitivity (0.81) and specificity (0.85) characteristics for detecting depression.Conclusions: The single-item DT performs satisfactorily relative to the PHQ-9 for detecting depression in newly diagnosed breast cancer patients. A cutoff score of 7 on the DT possesses the optimal sensitivity and specificity characteristics. The strength of these findings suggests that a careful psychosocial evaluation should follow a positive screen. Copyright (C) 2007 John Wiley & Sons, Ltd.