Ganglioside GD3 synthase (GD3S), a novel cancer drug target.
Ganglioside GD3 synthase (GD3S), a novel cancer drug target.
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DOI：
10.1016/j.apsb.2018.07.009
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Du G
中科院分区：
文献类型：
--
作者：
Liu J;Zheng X;Pang X;Li L;Wang J;Yang C;Du G
神经节苷脂是一类重要的含唾液酸的鞘糖脂，广泛分布于细胞外表面，在脑组织中也大量分布。具有三个糖基的二唾液酸神经节苷脂（GD3）和具有两个糖基的二唾液酸神经节苷脂（GD2）在癌症和神经退行性疾病等病理状况下显着增加。研究发现，GD3 和 GD2 通过介导细胞增殖、迁移、侵袭、粘附、血管生成以及预防肿瘤的免疫抑制，在癌症中发挥重要作用。 GD3合酶(GD3S)是GD3和GD2合成的调节酶，在肿瘤发生和癌症的发展中发挥重要作用。 GD3S作为药物靶点的研究可能对于发现癌症治疗新药具有重要意义。本综述将描述神经节苷脂及其在生理和病理条件下的作用； GD3 和 GD2 在癌症中的作用； GD3S 的表达、功能和机制及其作为癌症药物靶点的潜力。神经节苷脂GD3和GD2参与许多癌症并进一步发挥重要作用。 GD3合酶(GD3S)是唯一调节GD3和GD2生物合成的酶。本综述重点关注 GD3S 作为癌症新药物靶点的潜力。
Gangliosides are a class of important glycosphingolipids containing sialic acid that are widely distributed on the outer surface of cells and are abundantly distributed in brain tissue. Disialoganglioside with three glycosyl groups (GD3) and disialoganglioside with two glycosyl groups (GD2) are markedly increased in pathological conditions such as cancers and neurodegenerative diseases. GD3 and GD2 were found to play important roles in cancers by mediating cell proliferation, migration, invasion, adhesion, angiogenesis and in preventing immunosuppression of tumors. GD3 synthase (GD3S) is the regulatory enzyme of GD3 and GD2 synthesis, and is important in tumorigenesis and the development of cancers. The study of GD3S as a drug target may be of great significance for the discovery of new drugs for cancer treatment. This review will describe the gangliosides and their roles in physiological and pathological conditions; the roles of GD3 and GD2 in cancers; the expression, functions and mechanisms of GD3S, and its potential as a drug target in cancers. Gangliosides GD3 and GD2 are involved and further play important roles in many cancers. GD3 synthase (GD3S) is the only enzyme that regulates the biosynthesis of GD3 and GD2. The potential of GD3S to serve as a novel drug target in cancer is focused in this review.
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