Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor.-猫眼课题宝

Nrf2 的调频易位振荡，Nrf2 是一种像无线传感器一样发挥作用的转录因子。

DOI：

10.1042/bst20150060

发表时间：

2015

期刊：

Biochemical Society transactions

影响因子：

3.9

通讯作者：

中科院分区：

生物学3区

文献类型：

作者：

Xue M

核因子-红细胞2相关因子2 （Nrf2）在人类细胞中经历了从细胞质到细胞核的易位振荡，其频率调制与应激刺激的细胞保护反应的激活有关，这一发现提出了Nrf2在机制上类似于无线传感器的前景。在本文中，我们考虑了Nrf2振荡的新模型如何解决先前关于Nrf2调控的令人费解的实验发现，以及为什么它适合于目的。需要进一步的研究来评估振荡机制的普遍适用性，以及这种调节控制的特征是否可以在体内找到。这表明有多个潜在的强化受体激活Nrf2，这表明Nrf2的有效激活可以通过Nrf2系统兴奋剂的组合来改善健康和治疗疾病。

The discovery that nuclear factor erythroid 2-related factor 2 (Nrf2) undergoes translocational oscillations from cytoplasm to nucleus in human cells with frequency modulation linked to activation of a stress-stimulated cytoprotective response raises the prospect that the Nrf2 works mechanistically analogous to a wireless sensor. Herein, we consider how this new model of Nrf2 oscillation resolves previous inexplicable experimental findings on Nrf2 regulation and why it is fit-for-purpose. Further investigation is required to assess how generally applicable the oscillatory mechanism is and if characteristics of this regulatory control can be foundin vivo.It suggests there are multiple, potentially re-enforcing receptors for Nrf2 activation, indicating that potent Nrf2 activation for improved health and treatment of disease may be achieved through combination of Nrf2 system stimulants.