Volumes of association thalamic nuclei in schizophrenia:: a postmortem study
Volumes of association thalamic nuclei in schizophrenia:: a postmortem study
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DOI：
10.1016/s0920-9964(02)00307-9
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发表时间：
2003-04-01
影响因子：
4.5
通讯作者：
Bogerts, B
中科院分区：
文献类型：
--
作者：
Danos, P;Baumann, B;Bogerts, B
丘脑大联合核、背内侧核和枕内侧核被认为是联合皮层回路的重要组成部分。额叶、顶叶和颞叶的联合皮质区域反复与精神分裂症的神经病理学有关。因此，本尸检研究的目的是调查在这种疾病的联合丘脑核的体积。对12例精神分裂症患者和13例年龄、性别相匹配的正常对照者的大脑各半球全丘脑（塔尔）、MD和PUM体积进行了测量。精神分裂症患者的MD和PUM均表现出显著的体积减少，PUM的减少更为明显。精神分裂症组左半球（-19.7%，P =0.02）和右半球（-22.1%，P =0.01）的PUM体积显著减小。在精神分裂症组中，MD的体积在两个半球中减少。然而，仅左半球的体积减少显著（-9.3%，P=0.03）。精神分裂症患者左半球（-16.4%，P =0.003）和右半球（-15.2%，P =0.006）的塔尔体积也减少。丘脑体积与患者的病程或年龄之间无显著相关性。总之，目前的数据表明，体积减少的联合丘脑核在精神分裂症。这些解剖结果与精神分裂症可能与关联皮层网络紊乱有关的观点一致。然而，塔尔体积显著减少的结果表明，精神分裂症患者的额外丘脑核团的体积也可能减少。(C)2002 Elsevier Science B. V.保留所有权利。
The major association thalamic nuclei, the mediodorsal nucleus (MD) and the medial pulvinar nucleus (PUM) are regarded as important parts of the circuits among association cortical regions. Association cortical regions of the frontal, parietal and temporal lobes have been repeatedly implicated in the neuropathology of schizophrenia. Thus, the aim of the present postmortem study was to investigate the volumes of association thalamic nuclei in this disease. The volumes of the whole thalamus (THAL), MD and PUM were measured in each hemisphere of brains of 12 patients with schizophrenia and 13 age-matched and gender-matched normal control subjects without neuropsychiatric disorders. Patients with schizophrenia exhibited significant volume reductions in both the MD and the PUM, the reductions being more pronounced in the PUM. The volume of the PUM in the left (-19.7%, P=0.02) and right ( -22.1%, P=0.01) hemispheres was significantly reduced in the schizophrenia group. The volume of the MD was reduced in both hemispheres in the schizophrenia group. However, the volume reduction was only significant in the left hemisphere ( -9.3%, P=0.03). Patients with schizophrenia also exhibited a decreased volume of the THAL in the left ( -16.4%, P=0.003) and right (-15.2%, P=0.006) hemispheres. There were no significant correlations between thalamic volumes and duration of illness or age of the patients. In conclusion, the present data indicate volume reductions of association thalamic nuclei in schizophrenia. These anatomical findings are consistent with the view that schizophrenia may be associated with disturbances of association cortical networks. However, the findings of a substantial volume reduction of the THAL suggest that the volumes of additional thalamic nuclei may be also reduced in schizophrenia. (C) 2002 Elsevier Science B.V. All rights reserved.