Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine.
Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine.
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DOI：
10.12659/msm.889636
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发表时间：
2013-10-31
期刊：
影响因子：
--
通讯作者：
Chen C
中科院分区：
文献类型：
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作者：
Fang Y;Yao Q;Chen Z;Xiang J;William FE;Gibbs RA;Chen C
人类基因组学和生物技术的最新进展对医学研究和临床实践产生了深远的影响。个体基因组信息，包括DNA序列和基因表达谱，可用于许多复杂疾病的预测、预防、诊断和治疗。个性化医疗试图通过整合患者的基因组信息来为个体患者量身定制医疗护理。在胰腺癌的情况下，在美国癌症死亡的第四大原因，在许多基因以及血液，胰腺组织和胰液中的分子谱的改变最近被发现与肿瘤发生或癌症的预后密切相关。本文综述了在胰腺癌发病机制中起关键作用的重要基因、蛋白质和microRNA的最新研究进展，并为胰腺癌的个体化治疗提供启示。
Recent advances in human genomics and biotechnologies have profound impacts on medical research and clinical practice. Individual genomic information, including DNA sequences and gene expression profiles, can be used for prediction, prevention, diagnosis, and treatment for many complex diseases. Personalized medicine attempts to tailor medical care to individual patients by incorporating their genomic information. In a case of pancreatic cancer, the fourth leading cause of cancer death in the United States, alteration in many genes as well as molecular profiles in blood, pancreas tissue, and pancreas juice has recently been discovered to be closely associated with tumorigenesis or prognosis of the cancer. This review aims to summarize recent advances of important genes, proteins, and microRNAs that play a critical role in the pathogenesis of pancreatic cancer, and to provide implications for personalized medicine in pancreatic cancer.