Distribution and degranulation of airway mast cells in normal and asthmatic subjects
Distribution and degranulation of airway mast cells in normal and asthmatic subjects
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DOI：
10.1183/09031936.02.00275802
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发表时间：
2002-05-01
影响因子：
24.3
通讯作者：
James, AL
中科院分区：
文献类型：
--
作者：
Carroll, NG;Mutavdzic, S;James, AL
据推测，肥大细胞在气道壁上的分布和激活可能反映了它们在哮喘中的功能。对从致命性哮喘、非致命性哮喘和非哮喘控制病例的尸检中获得的软骨和膜性气道气道室内肥大细胞（完整和脱颗粒）的密度进行了检查。在软骨气道中，对照病例中肥大细胞的平均+/- SE密度为27 +/- 9细胞.mm(-2)。非致死性哮喘的情况相似 (24 +/- 2 cells.mm(-2))，但有所减少 (p
It was hypothesized that the distribution and activation of mast cells across the airway wall may reflect their function in asthma.The density of mast cells (intact and degranulated) within airway compartments in cartilaginous and membranous airways, obtained from autopsies on patients with fatal asthma, nonfatal asthma, and nonasthmatic control cases have been examined.In cartilaginous airways, the mean +/- SE density of mast cells in control cases was 27 +/- 9 cells.mm(-2). It was similar in nonfatal asthma (24 +/- 2 cells.mm(-2)) but reduced (p