Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia
Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia
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DOI：
10.1093/humrep/15.9.2033
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发表时间：
2000-09-01
影响因子：
6.1
通讯作者：
Johnson, MR
中科院分区：
文献类型：
--
作者：
Anim-Nyame, N;Sooranna, SR;Johnson, MR
在已确定的先兆子痫的横断面研究中发现瘦素浓度升高。在横断面研究中测量了瘦素的循环浓度以证实这些发现（19名先兆子痫妇女和13名正常妊娠对照），并在一项纵向研究中确定瘦素浓度增加的时间。（在妊娠16、20、24、28、32、36和38周从8名继续发展为先兆子痫的妇女和7名正常妊娠对照中获得的样品），在横断面研究中，先兆子痫妇女的血浆瘦素浓度显著高于正常对照组（P = 0.001）。在纵向研究中，发现循环瘦素浓度逐渐上升到32周，此后在正常人中略有下降。注定要发展先兆子痫的妇女中的浓度从妊娠20周开始一直较高（P = 0.04-0.003），并且与正常对照相比，随着先兆子痫的发展，从32周开始显著升高。这项研究证实，血浆瘦素浓度增加，在建立先兆子痫和报告的第一次，瘦素浓度升高先兆子痫是临床上明显的。
Leptin concentrations have been found to be elevated in cross-sectional studies of established pre-eclampsia. Circulating concentrations of leptin were measured in cross-sectional study to confirm these findings (19 women with pre-eclampsia and 13 normal pregnant controls) and in a longitudinal study to establish the timing of the increase in leptin concentrations (samples obtained at 16, 20, 24, 28, 32, 36 and 38 weeks gestation from eight women who went on to develop pre-eclampsia and seven normal pregnant controls), In the cross-sectional study, plasma leptin concentrations were significantly greater in women with pre-eclampsia than in normal controls (P = 0.001). In the longitudinal study, it was found that circulating leptin concentrations rose gradually to 32 weeks and thereafter declined slightly in normals. The concentrations in women destined to develop pre-eclampsia were consistently higher from 20 weeks gestation (P = 0.04-0.003) and, in contrast to the normal controls, rose markedly from 32 weeks as pre-eclampsia developed. This study confirms that plasma leptin concentrations are increased in established pre-eclampsia and reports for the first time that leptin concentrations are elevated before pre-eclampsia is clinically evident.