Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons
Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons
复制标题
DOI：
10.1155/2016/9839348
复制
发表时间：
2016-01-01
影响因子：
3.1
通讯作者：
Inestrosa, Nibaldo C.
中科院分区：
文献类型：
--
作者：
Cisternas, Pedro;Salazar, Paulina;Inestrosa, Nibaldo C.
在过去的几年中，一些报告提出，Wnt信号是一种通用的代谢调节器，这表明该途径在控制代谢通量中的作用。Wnt信号传导对几种神经元功能至关重要，但对该途径与能量代谢之间的相关性知之甚少。大脑对葡萄糖有很高的需求，葡萄糖主要用于能量生产。神经元将能量用于需要高能量水平的高度特定的过程，例如维持电位和合成神经递质。此外，在所有神经退行性疾病中均描述了重要的代谢障碍。尽管葡萄糖代谢在大脑中起着关键作用，但人们对参与调节这一过程的细胞途径知之甚少。我们在这里报告说，Wnt 5a诱导葡萄糖摄取和糖酵解速率的增加和戊糖磷酸途径的活性增加; Wnt 5a的作用需要细胞内产生一氧化氮。我们的数据表明，Wnt信号刺激神经元葡萄糖代谢，这种作用可能是重要的Wnt信号在神经退行性疾病中的神经保护作用。
In the last few years, several reports have proposed that Wnt signaling is a general metabolic regulator, suggesting a role for this pathway in the control of metabolic flux. Wnt signaling is critical for several neuronal functions, but little is known about the correlation between this pathway and energy metabolism. The brain has a high demand for glucose, which is mainly used for energy production. Neurons use energy for highly specific processes that require a high energy level, such as maintaining the electrical potential and synthesizing neurotransmitters. Moreover, an important metabolic impairment has been described in all neurodegenerative disorders. Despite the key role of glucose metabolism in the brain, little is known about the cellular pathways involved in regulating this process. We report here that Wnt5a induces an increase in glucose uptake and glycolytic rate and an increase in the activity of the pentose phosphate pathway; the effects of Wnt5a require the intracellular generation of nitric oxide. Our data suggest that Wnt signaling stimulates neuronal glucose metabolism, an effect that could be important for the reported neuroprotective role of Wnt signaling in neurodegenerative disorders.