REGIONAL ADIPOSE-TISSUE CELLULARITY IN RELATION TO METABOLISM IN YOUNG AND MIDDLE-AGED WOMEN
REGIONAL ADIPOSE-TISSUE CELLULARITY IN RELATION TO METABOLISM IN YOUNG AND MIDDLE-AGED WOMEN
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DOI：
10.1016/0026-0495(75)90038-4
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发表时间：
1975-01-01
影响因子：
9.8
通讯作者：
SMITH, U
中科院分区：
文献类型：
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作者：
KROTKIEWSKI, M;SJOSTROM, L;SMITH, U
随机选择31名52岁的女性和13名体重在理想体重±10%范围内的年轻女性（平均年龄22岁），对身体成分和脂肪细胞总数进行了研究。其中两名52岁的女性明显肥胖并被排除在外。还测定了脂肪组织厚度、脂肪细胞大小和数量的区域测定。中年妇女有更多的身体脂肪（BF），但较低的体细胞质量（BMF）比年轻组。中年女性的BF增加完全是由更大的脂肪细胞解释的，因为年轻女性的脂肪细胞总数明显更高。当身高、体重和体脂的差异匹配时，也发现了这种增加。年轻组的局部脂肪细胞数量也增加。在中年女性中，所有研究区域的局部脂肪细胞大小都有所增加，但腹部区域的增加尤其明显。不同区域的脂肪细胞大小之间的相关性最高的是上腹部和下腹部区域之间以及股骨和臀部区域之间。此外，血浆胰岛素水平与腹部脂肪细胞大小相关，而与股骨或臀肌区域的脂肪细胞大小无关。总之，数据可能表明腹部脂肪细胞对营养和/或激素因素比其他区域的脂肪细胞更敏感。这反过来可能表明存在不同的脂肪细胞群。
Body composition and total number of fat cells were investigated in 31 randomly selected women 52 yr of age and in 13 young women (mean age 22 yr) whose body weights were within ±10% of the ideal weight. Two of the 52-yr-old women were obviously obese and excluded. Regional determinations of adipose tissue thickness, fat cell size, and number were also determined. Middleaged women had more body fat (BF) but a lower body cell mass (BCM) than the younger group. The increased BF in the middle-aged women was exclusively explained by larger fat cells, since the younger women had a significantly higher total number of fat cells. This increase was also found when differences in height, body weight, and body fat were matched out. Local fat cell number was also increased in the younger group. Local fat cell size was increased in all regions investigated in the middle-aged women, but the increase was particularly pronounced in the abdominal region. The highest degrees of correlation between fat cell sizes of different regions were found between the epigastric and hypogastric regions and between femoral and gluteal regions. Furthermore, the plasma insulin levels correlated with the fat cell sizes of the abdominal region but not with those of the femoral or gluteal regions.In conclusion, the data might indicate that the fat cells of the abdominal region are more sensitive to nutritional and/or hormonal factors than those of other regions. This may in turn indicate the existence of different fat cell populations.