DNA - Nanotube artificial ion channels
DNA - Nanotube artificial ion channels
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DOI：
10.1021/ja044948v
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发表时间：
2004-12-08
影响因子：
15
通讯作者：
Martin, CR
中科院分区：
文献类型：
--
作者：
Harrell, CC;Kohli, P;Martin, CR
人们对开发模拟生物离子通道功能的化学装置有相当大的兴趣。我们最近描述了这样一种装置，它由嵌入聚合物膜中的单个圆锥形金纳米管组成。该装置模拟了电压门控离子通道的关键功能之一：强烈整流流过它的离子电流的能力。虽然细节仍在争论中，但很明显，生物离子通道中的离子电流整流更复杂，并且涉及通道的离子带电部分响应于跨膜电位变化的物理运动。我们在这里报告的人工离子通道，纠正离子电流流经他们通过这种“机电”机制。这些人工通道也是基于圆锥形的金纳米管，但具有由附着在纳米管壁上的单链DNA分子提供的关键机电响应。
There is considerable interest in developing chemical devices that mimic the function of biological ion channels. We recently described such a device, which consisted of a single conically shaped gold nanotube embedded within a polymeric membrane. This device mimicked one of the key functions of voltage-gated ion channels: the ability to strongly rectify the ionic current flowing through it. The data obtained were interpreted using a simple electrostatic model. While the details are still being debated, it is clear that ion-current-rectification in biological ion channels is more complicated and involves physical movement of an ionically charged portion of the channel in response to a change in the transmembrane potential. We report here artificial ion channels that rectify the ion current flowing through them via this “electromechanical” mechanism. These artificial channels are also based on conical gold nanotubes, but with the critical electromechanical response provided by single-stranded DNA molecules attached to the nanotube walls.