Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens.
Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens.
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切碎的！
DOI：
10.1016/j.it.2023.06.006
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发表时间：
2023
影响因子：
16.8
通讯作者：
Wu,Hao
中科院分区：
文献类型：
--
作者：
Healy,LiamB;Du,Gang;Wu,Hao
在最近的一篇文章中，He等人报告说，响应于饮食蛋白抗原，小鼠肠上皮细胞（IEC）积累了新发现的13 kDa的gasdermin D（GSDMD-N13）的N末端，该末端被半胱天冬酶-3/7切割。与pyroptotic 30-kDa片段不同，GSDMD-N13易位到细胞核，诱导CIITA和主要组织相容性复合体II类（MHCII）表达，以促进1型调节性T（T1 r）细胞发育，从而揭示其在平衡免疫和食物耐受中的作用。
In a recent article, He et al. report that, in response to dietary protein antigens, mouse intestinal epithelial cells (IECs) accumulate a newfound 13-kDa N terminus of gasdermin D (GSDMD-N13), cleaved by caspase-3/7. Unlike the pyroptotic 30-kDa fragment, GSDMD-N13 translocates to the nucleus, inducing CIITA and major histocompatibility complex class II (MHCII) expression to promote type 1 regulatory T (T1r) cell development, thus revealing its role in balancing immunity and food tolerance.