In vivo clonal analysis of aging hematopoietic stem cells.
In vivo clonal analysis of aging hematopoietic stem cells.
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DOI：
10.1016/j.mad.2020.111378
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发表时间：
2020-12
影响因子：
5.3
通讯作者：
Nakauchi H
中科院分区：
文献类型：
--
作者：
Yamamoto R;Nakauchi H
造血干细胞（hsc）具有自我更新能力和多系分化潜能两个关键特征。随着年龄的增长，这些关键特征逐渐发生变化。这被认为与血液系统疾病有关。然而，评估造血干细胞沿红细胞和血小板谱系（“五谱系追踪”）分化潜力的克隆体内分析尚未在衰老的骨髓中进行。相比之下，在年轻的HSC中，体内克隆分析结合五谱系追踪为我们提供了HSC生物学的新见解。在克隆水平上了解HSC衰老将有助于我们阐明衰老机制和疾病进展。我们回顾了在移植环境中克隆细胞水平上理解HSC衰老的最新进展。
Hematopoietic stem cells (HSCs) are characterized by two key features: Self-renewal ability and multilineage differentiation potential (multipotentiality). With aging, these key features gradually change. This is thought to be related to hematological diseases. However, clonal in vivo analysis assessing the potential of HSCs to differentiate along erythroid and platelet lineages (“five-lineage tracing”) has not been performed in the aged bone marrow. By contrast, in young HSCs clonal in vivo analysis combined with five-lineage tracing has provided us with novel insights into HSC biology. Understanding HSC aging at the clonal level will help us to elucidate aging mechanisms and disease progression. We review recent progress towards understanding HSC aging at the clonal cell level in the transplantation setting.
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DOI：
10.1056/nejmoa1409405
发表时间：
2014-12-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Genovese G;Kähler AK;Handsaker RE;Lindberg J;Rose SA;Bakhoum SF;Chambert K;Mick E;Neale BM;Fromer M;Purcell SM;Svantesson O;Landén M;Höglund M;Lehmann S;Gabriel SB;Moran JL;Lander ES;Sullivan PF;Sklar P;Grönberg H;Hultman CM;McCarroll SA
通讯作者：
McCarroll SA
影响因子：
23.9
作者：
Yamamoto R;Wilkinson AC;Ooehara J;Lan X;Lai CY;Nakauchi Y;Pritchard JK;Nakauchi H
通讯作者：
Nakauchi H
影响因子：
64.5
作者：
Kiel, MJ;Yilmaz, ÖH;Morrison, SJ
通讯作者：
Morrison, SJ
DOI：
10.1084/jem.20111490
发表时间：
2011-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dykstra B;Olthof S;Schreuder J;Ritsema M;de Haan G
通讯作者：
de Haan G
影响因子：
15.3
作者：
Sudo, K;Ema, H;Morita, Y;Nakauchi, H
通讯作者：
Nakauchi, H