T-CELL ACTIVATION BY THE CD28 LIGAND-B7 IS REQUIRED FOR CARDIAC ALLOGRAFT-REJECTION INVIVO
T-CELL ACTIVATION BY THE CD28 LIGAND-B7 IS REQUIRED FOR CARDIAC ALLOGRAFT-REJECTION INVIVO
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DOI：
10.1073/pnas.89.22.11102
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发表时间：
1992-11-15
影响因子：
11.1
通讯作者：
THOMPSON, CB
中科院分区：
文献类型：
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作者：
TURKA, LA;LINSLEY, PS;THOMPSON, CB
器官移植排斥反应是一个依赖T细胞的过程。同种异体反应性T细胞的激活需要由外源主要组织相容性复合体（MHC）编码的基因产物刺激T细胞受体/CD 3复合体。然而，越来越多的证据表明，除了T细胞受体占用，其他共刺激信号是必需的，以诱导T细胞活化。以前，在T细胞上表达的CD 28受体已被证明是可以提供共刺激的信号转导途径的表面组分。在体外，CD 28与其天然配体B7的相互作用，表达在活化的B细胞或巨噬细胞的表面上，可以作为共刺激物诱导抗原受体活化的T细胞的增殖和淋巴因子的产生。我们现在报告的证据表明，刺激T细胞的CD 28配体B7是一个必要的共刺激事件的排斥反应的MHC不相容的心脏同种异体移植物在体内。这些结果表明B7/CD 28活化途径在调节体内T细胞应答中起重要作用。
Organ graft rejection is a T-cell-dependent process. The activation of alloreactive T cells requires stimulation of the T-cell receptor/CD3 complex by foreign major histocompatibility complex (MHC)-encoded gene products. However, accumulating evidence suggests that, in addition to T-cell receptor occupancy, other costimulatory signals are required to induce T-cell activation. Previously, the CD28 receptor expressed on T cells has been shown to serve as a surface component of a signal transduction pathway that can provide costimulation. In vitro, interaction of CD28 with its natural ligand B7 expressed on the surface of activated B cells or macrophages can act as a costimulus to induce proliferation and lymphokine production in antigen receptor-activated T cells. We now report evidence that stimulation of T cells by the CD28 ligand B7 is a required costimulatory event for the rejection of a MHC-incompatible cardiac allograft in vivo. These results demonstrate that the B7/CD28 activation pathway plays an important role in regulating in vivo T-cell responses.