Cardiovascular function and circadian patterns in rats after area postrema lesions or prolonged food restriction
Cardiovascular function and circadian patterns in rats after area postrema lesions or prolonged food restriction
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DOI：
10.1016/s0304-3940(03)00739-0
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发表时间：
2003-10-16
影响因子：
2.5
通讯作者：
Contreras, RJ
中科院分区：
文献类型：
--
作者：
Curtis, KS;Krause, EG;Contreras, RJ
通过无线电遥测技术，研究了AP （APX）病变大鼠的后脑区（AP）在基线心血管功能中的作用，以及APX对心血管功能昼夜节律模式和摄食行为的影响。尽管有病变引起的吞咽减退和体重减轻，APX不影响平均动脉压（MAP）、心率（HR）或摄食的昼夜模式，但确实导致静息心率大幅下降（-60 bpm）。心动过缓与体重减轻无关，因为体重匹配的对照组的静息心率虽然从基线下降，但明显高于APX大鼠。在体重匹配的对照组中，当体重恢复到基线时，心率略有增加；然而，APX大鼠的心动过缓持续存在。这些结果表明，AP有助于静息HR，独立于体重减轻或HR或MAP的昼夜节律模式变化。(C) 2003年由爱思唯尔爱尔兰有限公司出版
The role of the area postrema (AP) in baseline cardiovascular function was evaluated by radio telemetry in rats with lesions of AP (APX), along with the effect of APX on circadian patterns of cardiovascular function and ingestive behavior. Despite lesion-induced hypophagia and body weight loss, APX did not affect circadian patterns of mean arterial pressure (MAP), heart rate (HR), or ingestion but did cause a substantial decrease (-60 bpm) in resting HR. The bradycardia was not attributable to weight loss, as resting HR in weight-matched controls, though decreased from baseline, was significantly greater than that in rats with APX. In weight-matched controls, HR increased slightly when weight returned to baseline; however, the bradycardia persisted in rats with APX. These results suggest that AP contributes to resting HR, independent of weight loss or changes in circadian patterns of HR or MAP. (C) 2003 Published by Elsevier Ireland Ltd.