Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task.
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task.
复制标题
促炎细胞因子白细胞介素 1-β 的努力相关激励效应：同时进行固定比例 5/食物喂养选择任务的研究。
DOI：
10.1007/s00213-013-3285-4
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发表时间：
2014
影响因子：
3.4
通讯作者：
Salamone,JohnD
中科院分区：
文献类型：
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作者：
Nunes,EricJ;Randall,PatrickA;Estrada,Alexavier;Epling,Brian;Hart,EvanE;Lee,ChristieA;Baqi,Younis;Müller,ChristaE;Correa,Mercè;Salamone,JohnD
基本原理 与努力相关的动机症状，例如无力和疲劳，在抑郁症和其他疾病患者中很常见。研究表明促炎细胞因子与抑郁症有关，并且细胞因子的施用可以在人类中诱发与努力相关的动机症状。目的本实验重点研究促炎细胞因子白细胞介素 1-β (IL-1β) 对努力相关选择行为的影响。方法对大鼠进行同步固定比例 5 杠杆按压/喂食选择程序进行测试，该程序 评估大鼠在同时存在但不太受欢迎的替代品（实验室饲料）的情况下选择偏爱食物（高碳水化合物颗粒）的倾向。结果IL-1β（1.0–4.0 μg/kg IP）改变了选择行为，显着减少了杠杆按压并增加了免费食物的摄入量。第二个实验评估了腺苷 A2A 拮抗剂 (E)-磷酸单-[3-[8-[2-(3-甲氧基苯基)乙烯基]-7-甲基-2,6-二氧代-1-丙-2-炔基-1,2,6,7-四氢嘌呤-3-基]丙基]酯二钠盐 (MSX-3) 逆转以下行为影响的能力： IL-1β。 MSX-3 减轻了 IL-1β 产生的与努力相关的损伤，增加了杠杆压力并减少了食物摄入量。在改变与努力相关的选择行为的相同剂量范围内，IL-1β在平行的自由喂养选择研究中没有改变食物摄入或偏好，这表明这些低剂量通常不会抑制食欲或改变对高碳水化合物颗粒的偏好。此外，IL-1β 不会影响核心体温。结论这些结果表明，IL-1β 可以减少对食物的渴望，即使是低剂量，也不会产生全身疾病、不适或食欲不振。这项研究对于细胞因子参与动机症状（例如无力和疲劳）具有重要意义。
RationaleEffort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans.ObjectivesThe present experiments focused on the effects of the pro-inflammatory cytokine interleukin 1-beta (IL-1β) on effort-related choice behavior.MethodsRats were tested on a concurrent fixed ratio 5 lever pressing/chow feeding choice procedure, which assesses the tendency of rats to work for a preferred food (high carbohydrate pellets) in the presence of a concurrently available but less preferred substitute (laboratory chow).ResultsIL-1β (1.0–4.0 μg/kg IP) shifted choice behavior, significantly decreasing lever pressing and increasing intake of the freely available chow. The second experiment assessed the ability of the adenosine A2Aantagonist (E)-phosphoric acid mono-[3-[8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl] propyl] ester disodium salt (MSX-3) to reverse the behavioral effects of IL-1β. MSX-3 attenuated the effort-related impairments produced by IL-1β, increasing lever pressing and also decreasing chow intake. In the same dose range that shifted effort-related choice behavior, IL-1β did not alter food intake or preference in parallel free-feeding choice studies, indicating that these low doses were not generally suppressing appetite or altering preference for the high carbohydrate pellets. In addition, IL-1β did not affect core body temperature.ConclusionsThese results indicate that IL-1β can reduce the tendency to work for food, even at low doses that do not produce a general sickness, malaise, or loss of appetite. This research has implications for the involvement of cytokines in motivational symptoms such as anergia and fatigue.