Distribution of high-risk HPV types among women in Sichuan province, China: a cross-sectional study
Distribution of high-risk HPV types among women in Sichuan province, China: a cross-sectional study
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DOI：
10.1186/s12870-019-1790-2
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发表时间：
2019-05-08
影响因子：
3.7
通讯作者：
He, Junyong
中科院分区：
文献类型：
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作者：
He, Lixia;He, Junyong
【摘要】：背景高危型人乳头瘤病毒(HR-HPV)持续感染是宫颈上皮内瘤变和浸润性宫颈癌的主要原因。调查该地区女性HR-HPV感染情况及病毒基因型分布。方法2015年1月至2016年12月对四川省20岁以上女性进行宫颈癌筛查，采用液基细胞学检测和流式细胞术-荧光杂交检测HPV-DNA。使用卡方检验（（2））评估频率表。结果在参与研究的17,319名20-85岁女性中，HR-HPV感染总体患病率为12.6%（2178/17,319）。最流行的病毒类型是 HPV-52，存在于 2.5% 的个体中，其次是 HPV-53 (1.6%)、HPV-58 (1.5%)、HPV-16 (1.1%)、HPV-56 (0.9%)、HPV-39 (0.8%)。在HSIL中，最常见的五种HR-HPV类型是HPV52、16、58、33和56。HSIL中的HPV16/18仅占HSIL的25.9%，而HPV31/33/45/52/58占56.8%。 65岁以上女性HR-HPV总体患病率为15.2%，显着高于其他年龄组的患病率（P
BackgroundPersistent infection with high-risk human papillomavirus (HR-HPV) is a major cause of cervical intraepithelial neoplasia and invasive cervical cancer. We investigated the prevalence of HR-HPV infection and distribution of viral genotypes among women in this area.MethodsWomen in Sichuan older than 20years were screened for cervical cancer between January 2015 and December 2016 using liquid-based cytology testing and a flow cytometry-fluorescence hybridization test for HPV-DNA. Frequency tables were evaluated using the chi-squared test ((2)).ResultsOf the 17,319 women aged 20-85years who participated in the study, Overall prevalence of HR-HPV infection was 12.6% (2178/17,319). The most prevalent viral type was HPV-52, which was present in 2.5% of individuals, followed by HPV-53 (1.6%), HPV-58 (1.5%), HPV-16 (1.1%), HPV-56 (0.9%), HPV-39 (0.8%). In HSIL, the five most common HR-HPV types were HPV52, 16, 58, 33 and 56. HPV16/18 in HSIL only makes up 25.9% of HSIL, whereas HPV31/33/45/52/58 make up 56.8%. Overall HR-HPV prevalence among women older than 65years was 15.2%, significantly higher than the prevalence in other age groups (P